Heart diseases affect a large part of the world's population. Studies have shown that these diseases are related to cardiac fat. Various medical diagnostic aid systems are developed to reduce these diseases. In this context, this paper presents a new approach to the segmentation of cardiac fat from Computed Tomography (CT) images. The study employs a clustering algorithm called Floor of Log (FoL). The advantage of this method is the significant drop in segmentation time. Support Vector Machine was used to learn the best FoL algorithm parameter as well as mathematical morphology techniques for noise removal. The time to segment cardiac fat on a CT is only 2.01 s on average. In contrast, literature works require more than one hour to perform segmentation. Therefore, this job is one of the fastest to segment an exam completely. The value of the Accuracy metric was 93.45% and Specificity of 95.52%. The proposed approach is automatic and requires less computational effort. With these results, the use of this approach for the segmentation of cardiac fat proves to be efficient, besides having good application times. Therefore, it has the potential to be a medical diagnostic aid tool. Consequently, it is possible to help experts achieve faster and more accurate results.
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http://dx.doi.org/10.1016/j.compmedimag.2019.101674 | DOI Listing |
Geroscience
January 2025
Center for Aging and Population Health, School of Public Health, University of Pittsburgh, 310 BelPB, 130 N. Bellefield Avenue, Pittsburgh, PA, 15213, USA.
Unintentional weight loss in older populations is linked to greater mortality and morbidity risks. This study aims to understand the metabolic mechanisms of unintentional weight loss and their relationship with body composition changes in older adults. We investigated plasma metabolite associations with weight and body composition changes over 5 years in 1335 participants (mean age 73.
View Article and Find Full Text PDFCardiovasc Drugs Ther
January 2025
Department of Cardiothoracic Surgery, Affiliated Hospital of Nantong University, Nantong, 226000, Jiangsu, China.
Purpose: Cardiac inflammation is a basic pathological process of diabetic cardiomyopathy (DCM). Inflammatory response is closely related to pyroptosis, which is a recently identified programmed cell death type. Curcumin (CUR) is a polyphenol extracted from turmeric and has been reported to be crucial in alleviating pyroptosis in DCM.
View Article and Find Full Text PDFInt J Biol Sci
January 2025
Division of Endocrinology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Dysregulated energy metabolism, particularly lipid metabolism disorders, has been identified as a key factor in the development of diabetic cardiomyopathy (DCM). Sirtuin 2 (SIRT2) is a deacetylase involved in the regulation of metabolism and cellular energy homeostasis, yet its role in the progression of DCM remains unclear. We observed significantly reduced SIRT2 expression in DCM model mice.
View Article and Find Full Text PDFDiscov Med (Cham)
January 2025
Institute of Biomedical Engineering, University of Toronto, Toronto, ON Canada.
Background: Microvascular dysfunction (MVD) is a recognized sign of disease in heart failure progression. Intact blood vessels exhibit abnormal vasoreactivity in early stage, subsequently deteriorating to rarefaction and reduced perfusion. In managing heart failure with preserved ejection fraction (HFpEF), earlier diagnosis is key to improving management.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Biology, Faculty of Science, Razi University, Kermanshah, Iran.
Background: Type 2 Diabetes Mellitus (T2DM) is closely associated with the development of vascular damage in the heart. In this study, the researchers aimed to determine whether Aerobic Training (AT) and Vitamin D supplementation (Vit D) could alleviate heart complications and vascular damage caused by diabetes. The effects of an eight-week AT program and Vit D on the expression of miR-1, IGF-1 genes, and VEGF-B in the cardiomyocytes of rats with T2DM.
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