Supramolecular chemistry opened up opportunities and prospects in biological studies. Numerous supramolecular systems are known which assume different shapes depending on the structure of the component molecules. Some of them are mixed systems. Ribbon-like supramolecular structures which are the main focus of this paper form complexes with proteins in a way which is a new type of interaction. Despite preserving the ribbon-like structure, it may also interact with proteins as a mixed system. In this way, it may be used as a carrier of drugs. In addition, hybrid systems created by a combination of ribbon-like supramolecular structures with carbon nanotubes were presented together with data from studies of these structures as drug-carrying systems. This paper presents an outline of the experimentally confirmed possible use of ribbon-like supramolecular systems.
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http://dx.doi.org/10.18388/abp.2019_2910 | DOI Listing |
Biomed Pharmacother
April 2024
Genentech, Inc. A member of the Roche Group, South San Francisco, CA, USA.
Lipopolysaccharide (LPS, endotoxin) is ubiquitous and represents a harmful contaminant of pharmaceutical compounds, recombinant biologicals and drug products. The pyrogen can induce severe immune responses and pathology in vitro and in vivo. Health authorities require strict control of endotoxin in parenteral drugs.
View Article and Find Full Text PDFACS Appl Mater Interfaces
February 2024
KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul 02841, Republic of Korea.
Most supramolecular systems were discovered by using a trial-and-error approach, leading to numerous synthetic efforts to obtain optimal supramolecular building blocks for selective guest encapsulation. Here, we report a simple coassembly strategy for preparing tamoxifen-selective supramolecular nanomaterials in an aqueous solution. The synthetic amphiphile molecule, 1,1,2,2-tetraphenylethylene (TPE), promotes large tamoxifen aggregate disassembly into smaller, discrete aggregates such as ribbon-like and micellar assemblies in coassembled solutions, enhancing the solubility and dispersion.
View Article and Find Full Text PDFSmall
February 2024
Chemical Sciences and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology (CSIR-NIIST), Thiruvananthapuram, Kerala, 695019, India.
A mechanistic understanding of the principles governing the hierarchical organization of supramolecular polymers offers a paradigm for tailoring synthetic molecular architectures at the nano to micrometric scales. Herein, the unconventional crystal growth mechanism of a supramolecular polymer of superbenzene(coronene)-diphenylalanine conjugate (Cr-FF ) is demonstrated. 3D electron diffraction (3D ED), a technique underexplored in supramolecular chemistry, is effectively utilized to gain a molecular-level understanding of the gradual growth of the initially formed poorly crystalline hairy, fibril-like supramolecular polymers into the ribbon-like crystallites.
View Article and Find Full Text PDFMacromol Rapid Commun
December 2023
The State Key Laboratory of Molecular Engineering of Polymers and Department of Macromolecular Science, Fudan University, Shanghai, 200433, China.
Although advances have been made in carbohydrate-based macromolecular self-assembly, harnessing epimers of carbohydrates to perform molecular assembly and further investigating the properties of supramolecular materials remain little explored. Herein, two classes of stereoisomeric glycolipid amphiphiles based on d-N-acetylgalactosamine (GalNAc) are reported, and they can aggregate into ribbon-like structures in the aqueous solution due to amphiphilic property, which allow to obtain glycocalyx-mimicking supramolecular materials. The subtle distinction in glycoside configuration of GalNAc-α-SSA and GalNAc-β-SSA dictates the different molecular packing in self-assembled structures.
View Article and Find Full Text PDFGels
March 2023
Faculty of Environmental Studies, Tottori University of Environmental Studies, Tottori 689-1111, Japan.
Rheology control is an important issue in many industrial products such as cosmetics and paints. Recently, low-molecular-weight compounds have attracted considerable attention as thickeners/gelators for various solvents; however, there is still a significant need for molecular design guidelines for industrial applications. Amidoamine oxides (AAOs), which are long-chain alkylamine oxides with three amide groups, are surfactants that act as hydrogelators.
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