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Exploring the cognitive effects of hearing loss in adult rats: Implications for visuospatial attention, social behavior, and prefrontal neural activity.
Neuroscience
January 2025
Department of Neurosurgery, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hanover, Germany; Cluster of Excellence Hearing4all, German Research Foundation, Hanover, Germany. Electronic address:
Age-related hearing loss in humans has been associated with cognitive decline, though the underlying mechanisms remain unknown. We investigated the long-term effects of hearing loss on attention, impulse control, social interaction, and neural activity within medial prefrontal cortex (mPFC) subregions. Hearing loss was induced in adult rats via intracochlear neomycin injection (n = 13), with non-operated rats as controls (n = 10).
View Article and Find Full Text PDFImproved intracochlear biopolymeric drug delivery system: an study.
Acta Otolaryngol
December 2024
Department of Otolaryngology - Head and Neck Surgery, University of Miami Ear Institute, University of Miami, Miller School of Medicine, Miami, FL, USA.
Background: The delivery of drugs into the inner ear is a challenging field of study due to the complex cochlear anatomy and physiology. The creation of an intracochlear device that allows for short- and long-term intracochlear delivery of the drugs with a minimal invasive technology is needed to prevent or treat conditions that can potentially prevent the development of permanent hearing loss.
Aim: This study intends to test the efficacy of DXM-infused PLGA microneedles created in our laboratory in an animal model of acute ototoxic injury.
Electrocochleography-Based Tonotopic Map: I. Place Coding of the Human Cochlea With Hearing Loss.
Ear Hear
December 2024
Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine in St. Louis, St Louis, Missouri, USA.
Article Synopsis
- - The study aims to map the tonotopy (frequency organization) of the human cochlea in vivo using cochlear implant electrodes, addressing challenges of past research that relied on cadaver and animal models.
- - Fifty patients with hearing loss underwent cochlear implantation, where their responses to sound stimuli were recorded to analyze how sound intensity and an artificial "third window" influence the tonotopic map.
- - Results showed notable deviations from the expected Greenwood model in the frequency-position function, especially at higher sound levels, indicating complexities in how the cochlea processes sound intensity.
Bilateral intracochlear hemorrhage: A rare onset of chronic myelogenous leukemia.
Clin Case Rep
April 2024
Division of Otorhinolaryngology, Department of Clinical Science, Intervention and Technology Karolinska Institutet Stockholm Sweden.
Acute onset of vertigo and hearing loss is rare in leukemic disorders. MRI can diagnose intracochlear hemorrhage as the underlying cause. The hearing can improve but if severe hearing loss preserves, cochlear implantation can be considered.
View Article and Find Full Text PDFIn Silico Localization of Perilymph Proteins Enriched in Meńier̀e Disease Using Mammalian Cochlear Single-cell Transcriptomics.
Otol Neurotol Open
March 2023
Auditory Development and Restoration Program, National Institute on Deafness and Other Communication Disorders, Bethesda, MD.
Hypothesis: Proteins enriched in the perilymph proteome of Meńier̀e disease (MD) patients may identify affected cell types. Utilizing single-cell transcriptome datasets from the mammalian cochlea, we hypothesize that these enriched perilymph proteins can be localized to specific cochlear cell types.
Background: The limited understanding of human inner ear pathologies and their associated biomolecular variations hinder efforts to develop disease-specific diagnostics and therapeutics.
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