AI Article Synopsis
- The study examined urinary bladder biopsies from various patient groups, including multiple sclerosis patients and diabetics, to analyze the presence of specific proteins.
- Findings indicated that vasoactive intestinal polypeptide (VIP) levels were not reduced in neuropathic bladders, and its reduction did not relate to levels of acetylcholinesterase, suggesting complex bladder function dynamics.
- Further investigation is needed to understand the role of VIP in neurogenic bladder conditions and its potential implications for bladder activity.
Article Abstract
Urinary bladder biopsies from 31 multiple sclerosis patients, 9 diabetics, 5 patients after transtrigonal phenolization and 20 control patients were stained for acetylcholinesterase, S100 and vasoactive intestinal polypeptide (VIP). The VIP immunoreactivity was not decreased in all neuropathic bladders and its depletion was not related to cholinergic depletion. There was no correlation between bladder over- or underactivity and VIP content. VIP can act as a modulator of detrusor function in normal conditions. The significance of its depletion in neurogenic bladders needs further elaboration.
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| http://dx.doi.org/10.1159/000281339 | DOI Listing |
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