The comparative activity of the methyglyoxalic bypass of the glycolysis has been studied in muscles of vertebrates and invertebrates. An assumption is advanced that the methylglyoxalic bypass is related to the energy exchange, dissociation of catabolism and anabolism of carbohydrates and proteins maintenance of the constant level of asymmetrical entropy in vivo.
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Glucose metabolism impairment in Parkinson's disease.
Brain Res Bull
July 2023
Department of Neurology, The Second Affiliated Hospital of Chongqing Medical University, 74 Linjiang Road, Yuzhong District, Chongqing 400010, China. Electronic address:
Impairments in systematic and regional glucose metabolism exist in patients with Parkinson's disease (PD) at every stage of the disease course, and such impairments are associated with the incidence, progression, and special phenotypes of PD, which affect each physiological process of glucose metabolism including glucose uptake, glycolysis, tricarboxylic acid cycle, oxidative phosphorylation, and pentose phosphate shunt pathway. These impairments may be attributed to various mechanisms, such as insulin resistance, oxidative stress, abnormal glycated modification, blood-brain-barrier dysfunction, and hyperglycemia-induced damages. These mechanisms could subsequently cause excessive methylglyoxal and reactive oxygen species production, neuroinflammation, abnormal aggregation of protein, mitochondrial dysfunction, and decreased dopamine, and finally result in energy supply insufficiency, neurotransmitter dysregulation, aggregation and phosphorylation of α-synuclein, and dopaminergic neuron loss.
View Article and Find Full Text PDFActivating Silent Glycolysis Bypasses in .
Biodes Res
May 2022
Max Planck Institute of Molecular Plant Physiology, Am Mühlenberg 1, 14476 Potsdam-Golm, Germany.
All living organisms share similar reactions within their central metabolism to provide precursors for all essential building blocks and reducing power. To identify whether alternative metabolic routes of glycolysis can operate in , we complementarily employed design, rational engineering, and adaptive laboratory evolution. First, we used a genome-scale model and identified two potential pathways within the metabolic network of this organism replacing canonical Embden-Meyerhof-Parnas (EMP) glycolysis to convert phosphosugars into organic acids.
View Article and Find Full Text PDFCombined Impact of Magnetic Force and Spaceflight Conditions on Physiology.
Int J Mol Sci
February 2022
Laboratory of Ecology of Pathogenic Bactreia, Gamaleya National Research Centre for Epidemiology and Microbiology, 123098 Moscow, Russia.
Changes in bacterial physiology caused by the combined action of the magnetic force and microgravity were studied in grown using a specially developed device aboard the International Space Station. The morphology and metabolism of grown under spaceflight (SF) or combined spaceflight and magnetic force (SF + MF) conditions were compared with ground cultivated bacteria grown under standard (control) or magnetic force (MF) conditions. SF, SF + MF, and MF conditions provided the up-regulation of Ag43 auto-transporter and cell auto-aggregation.
View Article and Find Full Text PDFThe Physiological Responses of Triggered by Phosphoribulokinase (PrkA) and Ribulose-1,5-Bisphosphate Carboxylase/Oxygenase (Rubisco).
Microorganisms
August 2020
Department of Chemical Engineering, National Chung Hsing University, Taichung City 40227, Taiwan..
Phosphoribulokinase (PrkA) and ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) have been proposed to create a heterologous Rubisco-based engineered pathway in for in situ CO recycling. While the feasibility of a Rubisco-based engineered pathway has been shown, heterologous expressions of PrkA and Rubisco also induced physiological responses in that may compete with CO recycling. In this study, the metabolic shifts caused by PrkA and Rubisco were investigated in recombinant strains where and genes (encodes phosphoenolpyruvate carboxylase and phosphate acetyltransferase, respectively) were deleted from MZLF ( BL21(DE3) Δ, Δ Δ).
View Article and Find Full Text PDFAssociation of transketolase polymorphisms with measures of polyneuropathy in patients with recently diagnosed diabetes.
Diabetes Metab Res Rev
May 2017
The GDS Group consists of M. Roden (speaker), H. Al-Hasani, A.E. Buyken, J. Eckel, G. Geerling C. Herder, A. Icks, J. Kotzka, O. Kuß, E. Lammert, J. Lundbom, D. Markgraf, K. Müssig, W. Rathmann, J. Szendrödi, D. Ziegler, and their co-workers who are responsible for the design and conduct of the GDS.
Background: Shunting of glycolytic intermediates into the pentose phosphate pathway has been suggested to protect from hyperglycaemia-induced microvascular damage. We hypothesized that genetic variability in the gene encoding transketolase, a key pentose phosphate pathway enzyme, contributes to early nerve dysfunction in recent-onset diabetes.
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