Frequency of chromosome aberrations in the liver cells of hepatectomized Wistar rats aged 3, 9, 12 and 18 months was studied. Changes in the number of chromosomes and damage of their structure at the metaphase stage of the first division hepatocytes are analyzed. The content of aneuploid cells was 1-3% of the total number of metaphases studied and did not change with the age of animals. Frequency of chromosomal aberrations increased with aging from 1.3 to 6.9 in rats aged 3 and 18 months, respectively, mainly due to chromatid-type aberrations.
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