The chain of causation can be broken if an independent actor intervenes between the defendant's negligence and the resulting injury.
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Histone Deacetylation in Alzheimer's Diseases (AD); Hope or Hype.
Cell Biochem Biophys
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Department of Medical Laboratories Technology, AL-Nisour University College, Baghdad, Iraq.
Histone acetylation is the process by which histone acetyltransferases (HATs) add an acetyl group to the N-terminal lysine residues of histones, resulting in a more open chromatin structure. Histone acetylation tends to increase gene expression more than methylation does. In the central nervous system (CNS), histone acetylation is essential for controlling the expression of genes linked to cognition and learning.
View Article and Find Full Text PDFTo increase trust in clinical research: Be worthy of trust and enhance the role of clinical research nurses.
J Clin Transl Sci
November 2024
Center for Clinical and Translational Science, The Rockefeller University, New York, NY, USA.
There has been an erosion of trust in medical care and clinical research, and this has raised issues about whether institutions and investigators conducting clinical research are worthy of trust. We review recent literature on research on trust and trustworthiness in the clinical research enterprise and identify opportunities to enhance trustworthiness, which will likely increase participant trust in clinical research. In addition, we review materials reporting the results of national polls related to the public's trust in different occupations.
View Article and Find Full Text PDFThe Complete Inpatient Record Using Comprehensive Electronic Data (CIRCE) project: A team-based approach to clinically validated, research-ready electronic health record data.
Learn Health Syst
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Department of Biostatistics, Epidemiology and Informatics University of Pennsylvania Perelman School of Medicine Philadelphia Pennsylvania USA.
Introduction: The rapid adoption of electronic health record (EHR) systems has resulted in extensive archives of data relevant to clinical research, hospital operations, and the development of learning health systems. However, EHR data are not frequently available, cleaned, standardized, validated, and ready for use by stakeholders. We describe an in-progress effort to overcome these challenges with cooperative, systematic data extraction and validation.
View Article and Find Full Text PDFUncertainty experienced by the critical patient upon discharge to the general ward: Care proposals from the perspective of Mishel's theory.
Nurs Crit Care
January 2025
Departament d'Infermeria, Universitat Rovira i Virgili, Campus Catalunya, Tarragona, Spain.
Background: The process of discharging the critical patient to the ward (discharge from critical care to the general ward-DCCW) is often described as an experience involving uncertainty which may affect the patient's quality of life and ability to cope. Coping with uncertainty is an individual response not related to the course of the illness that is dependent on external and internal resources and the ability to utilize them. Mishel's theory of uncertainty identifies aspects of care that can shape the experience of uncertainty associated with the illness.
View Article and Find Full Text PDFFactors associated with knowledge and practice regarding oxygen administration: A cross-sectional study among registered nurses working in wards and ICUs at Muhimbili National Hospital in Dar es Salaam, Tanzania.
PLoS One
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Clinical Nursing Department, Muhimbili University of Health and Allied Sciences (MUHAS), Dar es Salaam, Tanzania.
Background: Oxygen is a vital therapy approved by WHO, crucial for critically ill patients as a supplemental treatment. Nurses' pivotal role in oxygen administration is poorly understood. This study aimed to assess factors associated with oxygen administration to critically ill patients among nurses at Muhimbili National Hospital (MNH) in Dar es Salaam, Tanzania.
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