AI Article Synopsis
- Rodent's incisors have special enamel rich in iron that keeps growing as they age, making them interesting for studying how iron works in the body.
- Scientists removed a specific gene (ATG7) in mice that helps make enamel, which caused the teeth to turn white instead of yellow due to less iron moving into the enamel.
- The absence of ATG7 also led to extra teeth growing in places where they shouldn't, showing that healthy enamel growth in rodents relies on this gene's activity.
Article Abstract
The incisors of rodents comprise an iron-rich enamel and grow throughout adult life, making them unique models of iron metabolism and tissue homeostasis during aging. Here, we deleted (autophagy related 7) in murine ameloblasts, i.e. the epithelial cells that produce enamel. The absence of ATG7 blocked the transport of iron from ameloblasts into the maturing enamel, leading to a white instead of yellow surface of maxillary incisors. In aging mice, lack of ATG7 was associated with the growth of ectopic incisors inside severely deformed primordial incisors. These results suggest that 2 characteristic features of rodent incisors, i.e. deposition of iron on the enamel surface and stable growth during aging, depend on autophagic activity in ameloblasts. : ATG5: autophagy related 5; ATG7: autophagy related 7; CMV: cytomegalovirus; Cre: Cre recombinase; CT: computed tomography; FTH1: ferritin heavy polypeptide 1; GFP: green fluorescent protein; KRT5: keratin 5; KRT14: keratin 14; LGALS3: lectin, galactose binding, soluble 3; MAP1LC3/LC3: microtubule-associated protein 1 light chain 3; NCOA4: nuclear receptor coactivator 4; NRF2: nuclear factor, erythroid 2 like 2; SQSTM1: sequestosome 1.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8386597 | PMC |
| http://dx.doi.org/10.1080/15548627.2019.1709764 | DOI Listing |
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