AI Article Synopsis
- - The research introduces a new transgenic mouse model for familial hemiplegic migraine type 3 (FHM3) that allows for the observation of spontaneous cortical spreading depolarization (CSD), a key feature of migraine aura.
- - These mutant mice express a specific mutation in sodium channels, which facilitates the study of CSD events in a controlled laboratory setting.
- - The findings reveal that CSDs in the mice follow a pattern similar to what is seen in human migraine patients, suggesting this model could help in developing treatments for migraines and related conditions.
Article Abstract
Here we show, for the first time, spontaneous cortical spreading depolarization (CSD) events - the electrophysiological correlate of the migraine aura - in animals by using the first generated familial hemiplegic migraine type 3 (FHM3) transgenic mouse model. The mutant mice express L263V-mutated α1 subunits in voltage-gated Na 1.1 sodium channels (Scn1a ). CSDs consistently propagated from visual to motor cortex, recapitulating what has been shown in patients with migraine with aura. This model may be valuable for the preclinical study of migraine with aura and other diseases in which spreading depolarization is a prominent feature.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952313 | PMC |
| http://dx.doi.org/10.1002/acn3.50971 | DOI Listing |
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