Seven known echinulin-related indolediketopiperazine alkaloids (-) were isolated from the Vietnamese sediment-derived fungus . Using chiral HPLC, the enantiomers of cryptoechinuline B () were isolated as individual compounds for the first time. (+)-Cryptoechinuline B () exhibited neuroprotective activity in 6-OHDA-, paraquat-, and rotenone-induced in vitro models of Parkinson's disease. (-)-Cryptoechinuline B () and neoechinulin C () protected the neuronal cells against paraquat-induced damage in a Parkinson's disease model. Neoechinulin B () exhibited cytoprotective activity in a rotenone-induced model, and neoechinulin () showed activity in the 6-OHDA-induced model.
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| http://dx.doi.org/10.3390/molecules25010061 | DOI Listing |
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