FOXP3+ and CD25+ cells are reduced in patients with stage IV, grade C periodontitis: A comparative clinical study.

J Periodontal Res

Integrated Dental Clinic, Department of Dental Materials and Prosthodontics, School of Dentistry of Ribeirão Preto (FORP/USP), University of São Paulo, Ribeirão Preto, Brazil.

Published: June 2020

AI Article Synopsis

  • The study investigates the role of regulatory T cells (Tregs) as immunomarkers in tissues affected by periodontitis compared to healthy gingiva.
  • It evaluates the presence of specific markers (CD4, CD25, FOXP3) in different stages of periodontitis using tissue samples from 30 patients.
  • The findings show higher levels of Treg markers in periodontitis patients, indicating their potential involvement in bone regeneration strategies during treatment.

Article Abstract

Background And Objective: Some studies suggest that regulatory T cells (Tregs) have suppressive effects on inflammatory osteolysis. The aim of this study was to evaluate Treg immunomarkers in periodontitis-affected tissues from patients with periodontitis and clinically healthy gingiva (control).

Material And Methods: The presence and distribution of positive cells for CD4, CD25 and FOXP3 (Treg immunomarkers) in periodontitis-affected tissues (epithelium and lamina propria) of 30 patients (ten per group) with a diagnosis of stage IV, grade C periodontitis (IV-C), stage III, grade B periodontitis (III-B) and the control were evaluated. A two-way ANOVA followed by Fisher's LSD test was used to demonstrate differences between the groups and immunomarkers; Student's t test was used to demonstrate differences between the epithelium and the lamina propria.

Results: Both IV-C and III-B periodontitis presented a significantly high proportion of immune-stained cells for all immunomarkers when compared to the control group. Notably, CD25+ and FOXP3+ cells were detected in a significantly higher number in III-B than IV-C periodontitis (P < .05).

Conclusion: Our results suggest the participation of Tregs on the osteoimmunological mechanisms in IV-C and III-B periodontitis patients, notably contributing to strategies for alveolar bone regeneration in clinical treatment decisions.

Download full-text PDF

Source
http://dx.doi.org/10.1111/jre.12721DOI Listing

Publication Analysis

Top Keywords

grade periodontitis
12
stage grade
8
treg immunomarkers
8
immunomarkers periodontitis-affected
8
periodontitis-affected tissues
8
epithelium lamina
8
test demonstrate
8
demonstrate differences
8
periodontitis
6
cells
5

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!