Objective: To assess the outcomes and potential predictors of residual leak after implantation of the GORE CARDIOFORM Septal Occluder (GSO) in secundum atrial septal defects (ASDs).
Background: The non-self-centering design of the GSO could lead to residual leak at the edge of the device. Outcomes of residual leak are poorly understood.
Methods: Retrospective, multicenter review of patients treated with the GSO for the pivotal and continued access study. Procedural, echocardiographic, and follow up data were reviewed. Multivariate analysis was performed to determine predictors of leak at implant and outcomes of these leaks.
Results: There were 370 total ASD device closures with the GSO, 65 (17.56%) of which were found to have residual leak at implantation. Patients with residual leak had larger defects (10.33 ± 3.05 mm vs. 9.13 ± 2.89 mm, p = .006) and smaller aortic rims (4.87 ± 3.33 mm vs. 6.17 ± 3.78 mm, p = .019), as compared to those without leak. Larger devices were implanted (p = .008) and more devices per case (p = .007) were utilized in the residual leak cohort as compared to those without leak. Overall, among patients with residual leak, there was a significant decrease in leak size over 1 year, from 1.55 ± 0.75 mm to 0.25 ± 0.74 mm (p < .001), with the majority (87.6%) disappearing by 12-month follow-up.
Conclusions: Residual leak at implantation can be seen after ASD device closure with the GSO, more commonly in larger defects with smaller retroaortic rims. The vast majority of these leaks completely resolve by 1 year follow up.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/ccd.28666 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Physiological basis of non-invasive ventilation in the newborn.
Semin Perinatol
December 2024
Department of Women and Children's Health, School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom; Neonatal Intensive Care Unit, University of Patras, Patras, Greece. Electronic address:
Non-invasive ventilation (NIV) is a form of respiratory support provided primarily to preterm born infants in an effort to avoid any endotracheal intubation or as a weaning step following invasive ventilation. In the context of the respiratory distress syndrome of the newborn, NIV could target and partially reverse specific pathophysiological phenomena, by improving alveolar recruitment and establishing adequate functional residual capacity. It can also assist in minimizing lung injury by avoiding excessive pressure delivery, which can be harmful for the developing lung.
View Article and Find Full Text PDFIs Laparoscopic Common Bile Duct Exploration Safe in Patients with Acute Cholangitis Caused by Common Bile Duct Stones? Results of a Systematic Review.
J Laparoendosc Adv Surg Tech A
January 2025
A21 Surgery Department, Faculty of Medicine of Tunis, Charles Nicolle Hospital, Tunis El Manar University, Tunis, Tunisia.
The traditional method of performing open common bile duct exploration (OCBDE) was replaced by a less invasive procedure known as laparoscopic common bile duct exploration (LCBDE) in elective surgery. But at present, the application of this technique is considered novel and controversial to treat acute cholangitis (AC). The aim of our systematic review was to investigate the safety and efficacy of laparoscopic surgery in patients with AC.
View Article and Find Full Text PDFComparative Endothelialization of the Watchman Plug Device and LACBES Pacifier Occluder after Left Atrial Appendage Closure.
Rev Cardiovasc Med
December 2024
Department of Cardiology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 200011 Shanghai, China.
Article Synopsis
- Left atrial appendage closure (LAAC) is an alternative for patients with nonvalvular atrial fibrillation (NVAF) to avoid oral anticoagulants, but issues like incomplete device endothelialization (IDE) can lead to complications.
- A study compared the endothelialization rates after implantation of two devices: the Watchman plug and the LACBES occluder, in 201 patients, using cardiac computed tomography angiography (CCTA).
- Results showed that the LACBES occluder had a higher IDE rate at both 3 and 6 months compared to the Watchman device, indicating that it takes longer for the LACBES to achieve complete endothelialization after LAAC.
Middle ear secretions following spontaneous CSF leak repair may represent effusion rather than CSF leak.
Eur Arch Otorhinolaryngol
December 2024
Departments of Otolaryngology-Head and Neck Surgery and Maxillofacial Surgery, School of Medicine, Tel Aviv Sourasky Medical Center, Tel-Aviv University, Tel Aviv, 6423907, Israel.
Objective: To characterize middle ear (ME) effusion still present 2 months after repair surgery for spontaneous cerebrospinal fluid (CSF) leak via the temporal bone (TB).
Study Design: A retrospective chart review (2011-2022).
Setting: Tertiary referral academic center.
Evaluation of cross-linkers in the design of immobilized multi isomerase cascade for the preparation of rare sugars.
Int J Biol Macromol
December 2024
School of Chemistry and Life Sciences, Suzhou University of Science and Technology, Suzhou 215009, China. Electronic address:
The cascade of sugar isomerases is one of the most practical methods for producing rare sugars, and enzyme immobilization endows it with high economic efficiency, operational convenience and reusability. However, the most employed cross-linker glutaraldehyde (GA) has the disadvantages of enzyme deactivation and limitation of substrate binding. Herein, three compounds, glyoxal, GA, and 2,5-furandicarboxaldehyde (DFF) were evaluated within a previously developed cascade comprising ribose-5-phosphate isomerase and D-tagatose-3-epimerase to prepare D-ribulose form D-xylose.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!