Background: The relationship between thermal stress and health has been only marginally investigated in North Africa. This study aimed to estimate the short-term effect of heat on total mortality, in the city of Tunis in 2005-2007, using time series analysis.
Methods: The study period was restricted to the summer season (May-October) and heat effect was assessed using maximum temperature as exposure variable. We estimated the breakpoint above which heat-related mortality begins to increase using a segmented linear regression. A Poisson Generalized Estimating Equations (GEE) model was then used to estimate the impact of heat on daily mortality. Models were adjusted for nitrogen dioxide (NO), trend, calendar month, day of the week, the Ramadan period, and holidays.
Results: The estimated breakpoint was 31.5°C (standard deviation: 0.9°C). After adjustment for potential confounders, the daily mortality increased significantly by 2.00% [95% confidence interval: 0.68-3.16] for a 1°C increase in daily maximum temperature above the breakpoint. An increase of 10mg/m in NO was associated with a significant increase in daily mortality (0.48% [0.08-0.88]).
Conclusion: There is an important effect of heat on daily mortality in the city of Tunis. This is the first evaluation of such an association in a North African city with hot and dry summers and a lower middle economy.
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http://dx.doi.org/10.1016/j.respe.2019.09.007 | DOI Listing |
Porcine Health Manag
December 2024
Pig Development Department, Animal and Grassland Research and Innovation Centre, Teagasc Moorepark, P61C996, Fermoy, Co. Cork, Ireland.
Background: Oral fluid contains analytes that may be reflective of health and welfare in pig herds. Additionally, oral fluid collection is a more convenient and cost-effective option when compared to blood sampling, increasing the potential of oral fluid as a non-invasive alternative tool. While a growing number of biomarkers can be measured in porcine oral fluid, the use of these analytes to compare commercial herds in veterinary practice is still limited.
View Article and Find Full Text PDFBMC Urol
December 2024
Department of Radiation Oncology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.
Background: Immune checkpoint inhibitors (ICIs) alone or in combination with standard chemotherapy for advanced urothelial carcinoma (UC) have been tested as first-line treatment in clinical trials. This study aimed to evaluate the clinical outcomes of programmed cell death 1 (PD-1) inhibitor alone or combined with chemotherapy for patients with locally advanced or metastatic UC in a real world clinical care setting, and sought to identify prognostic factors for overall survival (OS).
Methods: A retrospective, real-world study involving 35 locally advanced or metastatic UC patients treated with PD-1 inhibitor alone or in combination with chemotherapy was conducted.
Anticancer Res
January 2025
Department of Thoracic Oncology, Osaka Habikino Medical Center, Osaka, Japan.
Background/aim: The clinical benefits of durvalumab consolidation therapy following concurrent chemoradiotherapy (CCRT) with daily low-dose carboplatin in elderly patients with unresectable, locally advanced non-small cell lung cancer (NSCLC) remain unclear.
Patients And Methods: This was a single-institution retrospective cohort study. We analyzed the medical records of consecutive patients diagnosed with NSCLC who received CCRT with daily low-dose carboplatin from April 2014 to March 2021.
J Aquat Anim Health
December 2024
Virginia Institute of Marine Science, William & Mary, Gloucester Point, Virginia, USA.
Objective: The dinoflagellate Alexandrium monilatum forms blooms during summer in tributaries of the lower Chesapeake Bay. Questions persist about the potential for A. monilatum to negatively affect aquatic organisms.
View Article and Find Full Text PDFSci Rep
December 2024
MARE - Marine and Environment Sciences Centre/ARNET - Aquatic Research Network, Ispa - Instituto Universitário, Lisboa, Portugal.
While numerous studies have established correlations between parasite load and negative effects on their hosts, establishing causality is more challenging because parasites can directly compromise host condition and survival or simply opportunistically thrive on an already weakened host. Here, we evaluated whether Ixodes uriae, a widespread seabird tick, can cause a decrease in growth parameters (body mass, bill length and growth rates) and survival of chicks of a colonially seabird, the black-browed albatross (Thalassarche melanophris) breeding on New Island (West Falkland). To investigate this, we daily removed the ticks from 28 randomly selected chicks during their first 14 days of life (treated chicks) and compared their growth and survival with 49 chicks of a control group.
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