Sex is a key modifier of neurological disease outcomes. Microglia are implicated in neurological diseases and modulated by microRNAs, but it is unknown whether microglial microRNAs have sex-specific influences on disease. We show in mice that microglial microRNA expression differs in males and females and that loss of microRNAs leads to sex-specific changes in the microglial transcriptome and tau pathology. These findings suggest that microglial microRNAs influence tau pathogenesis in a sex-specific manner.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7394069 | PMC |
| http://dx.doi.org/10.1038/s41593-019-0560-7 | DOI Listing |
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