Background: the shock index (SI) defined by the ratio of systolic blood pressure to heart rate was demonstrated as a simple tool in the triage and orientation of severe trauma patients to trauma centers.
Aim: To assess the prognostic value of the SI ≥ 1 in terms of mortality in severe trauma patients admitted to the emergency room.
Methods: We performed a prospective, observational and descriptive study with the inclusion of severe trauma patients over the age of 18 years admitted to the Vital Emergency Room over a 21-month period. SI was calculated at admission: SI = heart rate / systolic blood pressure, a SI threshold value ≥1 was fixed to define two groups: SI<1 and SI≥1.
Results: A total of 290 trauma patients were included, 231 (79%) had a SI<1, whereas 59 (21%) had an SI≥1. Mean age was 43.5 ± 18 years, 82% were male. There was a significant difference in hospital mortality at 7 days and at 30 days between the two groups respectively (group SI<1 vs group SI≥1): [12% vs 40%; p <0.001 and 15% vs 47%; p <0.001]. In multivariate analysis, SI≥1 appears as an independent factor of hospital mortality at 7 days [OR = 2.03; 95% CI = 1.3-3.3; p =0.001] and at 30 days [OR = 2.69; 95% CI = 1.4- 5; p =0.002].
Conclusion: In severe trauma patients admitted to the emergency department; a SI ≥1 represents a predictive factor of hospital mortality at 7 days and one month.
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Lipids Health Dis
January 2025
Emergency surgery Dapartment (Trauma center), The First Affiliated Hospital, College of Clinical Medicine, Henan University of Science and Technology, Luoyang, 471003, Henan, China.
Lipid metabolism in cancer is characterized by dysregulated lipid regulation and utilization, critical for promoting tumor growth, survival, and resistance to therapy. Pancreatic cancer (PC) is a highly aggressive malignancy of the gastrointestinal tract that has a dismal 5-year survival rate of less than 10%. Given the essential function of the pancreas in digestion, cancer progression severely disrupts its function.
View Article and Find Full Text PDFAnn Gen Psychiatry
January 2025
Department of Psychiatry and Psychotherapy, Semmelweis University, 1083 Balassa utca 6, Budapest, Hungary.
Background: Increased levels of emotion dysregulation and impulsive behavior are overlapping symptoms in adult Attention-Deficit/Hyperactivity Disorder (aADHD) and Borderline Personality Disorder (BPD), both symptom domains reflecting on inhibitory control, although from different angles. Our aims were to describe their differences in the above conditions, investigate their associations with childhood traumatization, and to explore the potential mediation of emotion dysregulation and impulsivity between childhood traumas and personality functioning.
Methods: Young adults between 18 and 36 years diagnosed with aADHD (n = 100) and BPD (n = 63) were investigated with structured clinical interviews, while age-matched healthy controls (n = 100) were screened for psychiatric disorders.
BMC Psychiatry
January 2025
Department of Clinical Psychology and Psychotherapy, Institute of Psychology, Goethe University Frankfurt, Varrentrappstr. 40-42, 60486, Frankfurt am Main, Germany.
Background: Greater therapeutic alliance has been associated with an improved treatment outcome in various clinical populations. However, there is a lack of evidence for this association in posttraumatic stress disorder (PTSD) in young patients. We therefore investigated the development of the therapeutic alliance during Developmentally adapted cognitive processing therapy (D-CPT) in adolescents and young adults with PTSD following abuse to answer the question whether there was a connection between the therapeutic alliance and symptom reduction.
View Article and Find Full Text PDFInflamm Res
January 2025
Department of Anesthesiology, Critical Care, and Surgery, Duke University School of Medicine, Durham, NC, USA.
Background: Mitochondria generate the adenosine triphosphate (ATP) necessary for eukaryotic cells, serving as their primary energy suppliers, and contribute to host defense by producing reactive oxygen species. In many critical illnesses, including sepsis, major trauma, and heatstroke, the vicious cycle between activated coagulation and inflammation results in tissue hypoxia-induced mitochondrial dysfunction, and impaired mitochondrial function contributes to thromboinflammation and cell death.
Methods: A computer-based online search was performed using the PubMed and Web of Science databases for published articles concerning sepsis, trauma, critical illnesses, cell death, mitochondria, inflammation, coagulopathy, and organ dysfunction.
Neurosurg Rev
January 2025
Department of Neurosurgery, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.
To explore temporal dynamics of cerebral herniation through the calvarial defect after decompressive craniectomy. To investigate patterns of hemispheric asymmetry in ischemic stroke and traumatic brain injury after decompressive craniectomy.To assess clinical implications of hemispheric asymmetry evaluation in order to minimize cranioplasty complications.
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