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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6908589 | PMC |
| http://dx.doi.org/10.1038/s41392-019-0096-z | DOI Listing |
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RAF family kinases are RAS-activated switches that initiate signalling through the MAP kinase cascade to control cellular proliferation, differentiation and survival. RAF activity is tightly regulated and inappropriate activation is a frequent cause of cancer; however, the structural basis for RAF regulation is poorly understood at present. Here we use cryo-electron microscopy to determine autoinhibited and active-state structures of full-length BRAF in complexes with MEK1 and a 14-3-3 dimer.
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