[A case of farmer's lung associated with allergic bronchopulmonary aspergillosis].

Rev Mal Respir

Service de pneumologie, oncologie et allergologie respiratoires, Hôpital universitaire de Besançon, CHU de Besançon, CHU Jean-Minjoz, 3, boulevard Fleming, 25000 Besançon, France; UMR-CNRS 6249 Chrono-environnement, université de Franche-Comté, 25000 Besançon, France.

Published: January 2020

AI Article Synopsis

  • A 38-year-old French farmer experienced fever and difficulty breathing for a month that didn’t improve with antibiotics, leading to a diagnosis of farmer's lung and allergic bronchopulmonary aspergillosis.
  • The diagnosis was based on clinical, biological, functional, and radiological evidence, following established criteria.
  • Treatment with antigen avoidance and corticosteroids led to a favorable outcome, suggesting that there may be shared risk factors and immune mechanisms between hypersensitivity pneumonitis and allergic bronchopulmonary aspergillosis.

Article Abstract

Hypersensitivity pneumonitis and allergic bronchopulmonary aspergillosis are two forms of lung disease with presumed distinct immunoallergic mechanisms. We report the observation of a 38-year-old French farmer who, for one month, had fever and dyspnoea resistant to antibiotic therapy. A diagnosis of farmer's lung, and allergic bronchopulmonary aspergillosis was made on clinical, biological, functional and radiological evidence and according to the criteria established. The evolution was favorable with antigenic eviction and corticosteroid therapy. This observation is to our knowledge the 5 case that describes the association of hypersensitivity pneumonitis and allergic bronchopulmonary aspergillosis. It suggests the existence of risk factors and immunoallergic mechanisms common to both diseases and discusses the hypothesis that the same antigen(s) is (are) responsible for them.

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Source
http://dx.doi.org/10.1016/j.rmr.2019.11.642DOI Listing

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