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Inherited metabolic epilepsies-established diseases, new approaches.
Epilepsia Open
December 2024
Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity. These characteristics make it particularly challenging to establish their targeted therapies, and many of the IMEs are treated nowadays only symptomatically and supportively.
View Article and Find Full Text PDFEffective multicolor visual biosensor for ochratoxin A detection enabled by DNAzyme catalysis and gold nanorod etching.
Mikrochim Acta
December 2024
Key Laboratory of Chemical Sensing & Analysis in Universities of Shandong, School of Chemistry and Chemical Engineering, University of Jinan, Jinan, 250022, People's Republic of China.
A novel detection technique is introduced that offers sensitive and reliable ochratoxin A (OTA) detection. The method leverages the etching of gold nanorods (AuNRs) stabilized by hexadecyl trimethyl ammonium bromide (CTAB) using the oxidized form of 3,3',5,5'-tetramethyl benzidine sulfate (TMB), creating a susceptible multicolor visual detection system for OTA. The visual detection is enabled by Mg-assisted DNAzyme catalysis combined with the catalytic hairpin assembly (CHA) signal amplification strategy.
View Article and Find Full Text PDFEffects of Hydrolysed Poultry Byproduct Meal on Metabolic, Inflammatory and Oxidative Parameters in Cats.
J Anim Physiol Anim Nutr (Berl)
December 2024
Department of Veterinary Clinic and Surgery, School of Agricultural and Veterinary Sciences (FCAV), São Paulo State University-UNESP, Jaboticabal, Brazil.
Hydrolysed proteins are of interest owing to their potential effects on metabolic and physiological responses, low allergenicity and high digestibility. This study aimed to evaluate the use of hydrolysed poultry byproduct meal (HPM) as a replacement for conventional poultry byproduct meal (PBM) as a protein source and to study its effects on serum cytokines, angiotensin-converting enzyme (ACE) activity, serum antioxidant parameters, blood pressure, and urinary parameters in cats. The replacement of PBM with HPM was evaluated using five formulations with similar chemical compositions: control (PBM as the sole protein source) and the inclusion of 5%, 10%, 20%, and 30% HPM (on an as-fed basis).
View Article and Find Full Text PDFFatty Acid Oxidation-Glycolysis Metabolic Transition Affects ECM Homeostasis in Silica-Induced Pulmonary Fibrosis.
Adv Sci (Weinh)
December 2024
Department of Occupational Medical and Environmental Health, Key Laboratory of Modern Toxicology of Ministry of Education, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.
Silicosis is a fatal occupational pulmonary disease that is characterized by irreversible replacement of lung parenchyma by aberrant Exracellular matrix (ECM). Metabolic reprogramming is a crucial mechanism for fibrosis. However, how the metabolic rewiring shifts the ECM homeostasis toward overaccumulation remains unclear.
View Article and Find Full Text PDFBioisosteric replacement of pyridoxal-5'-phosphate to pyridoxal-5'-tetrazole targeting Bacillus subtilis GabR.
Protein Sci
January 2025
Department of Chemistry and Biochemistry, Loyola University Chicago, Chicago, Illinois, USA.
Antimicrobial resistance is a significant cause of mortality globally due to infections, a trend that is expected to continue to rise. As existing treatments fail and new drug discovery slows, the urgency to develop novel antimicrobial therapeutics grows stronger. One promising strategy involves targeting bacterial systems exclusive to pathogens, such as the transcription regulator protein GabR.
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