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Effectiveness of Manual Bronchial Clearance Techniques in the Treatment of Bronchiolitis.
Life (Basel)
December 2024
Health and Movement Research Group, Universidad Santiago de Cali, Cali 760001, Colombia.
Background: Bronchiolitis is a seasonal viral infection of the respiratory tract that causes numerous childhood hospitalizations annually. Treatments vary based on severity, with mild cases requiring fluids and moderate to severe cases involving hospitalization with oxygen therapy, bronchodilators, and chest physiotherapy. Manual bronchial clearance techniques differ between Anglo-Saxon and European schools, and their effectiveness remains a subject of debate.
View Article and Find Full Text PDFIntranasal exposure to commensal bacterium Rothia mucilaginosa protects against influenza A virus infection.
Antiviral Res
February 2025
INSERM, Research Center for Respiratory Diseases, UMR 1100, University of Tours, France. Electronic address:
The respiratory tract hosts a diverse microbial community whose composition varies with anatomical location and throughout life. Rothia mucilaginosa, a common commensal of the upper respiratory tract and oral cavity, has recently been recognized for its ability to inhibit bacteria-triggered pro-inflammatory responses. However, its role in modulating the immune response to viral infections such as influenza A virus (IAV) pneumonia, remains unknown.
View Article and Find Full Text PDFArticle Synopsis
- - The study highlights the connection between alcohol consumption and lung cancer, focusing on the inactivating mutation in the ALDH2 enzyme prevalent in Asian populations, which impacts acetaldehyde clearance.
- - Through a bioinformatic analysis of multi-omics data, researchers found that ALDH2 is significantly expressed in healthy lung tissue but less so in lung adenocarcinoma (LUAD), affecting key cellular processes and correlating with poorer patient prognosis.
- - The findings suggest that understanding ALDH2's role in lung cancer could lead to its use as a prognostic marker and a target for therapies aimed at enhancing immune responses in LUAD patients.
Development of an inhalable contrast agent targeting the respiratory tract mucus layer for pulmonary ultrasonic imaging.
Sci Rep
December 2024
Joint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, Chapel Hill, NC, 27599, USA.
Impaired mucociliary transport is a distinguishing sign of cystic fibrosis, but current methods of evaluation are invasive or expose young patients to ionizing radiation. Contrast-enhanced ultrasound imaging may provide a feasible alternative. We formulated a cationic microbubble ultrasound contrast agent, to optimize adhesion to the respiratory mucus layer when inhaled.
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