AI Article Synopsis
- Current research focuses on the eco-friendly production of silver-doped titanium dioxide (Ag/TiO) nanoparticles using plant extracts as a reducing agent and evaluates their antimicrobial and anticancer properties.
- Characterization techniques such as FTIR, XRD, FE-SEM EDS, and TEM were used to analyze the structure and properties of the synthesized nanoparticles, which showed significant antibacterial and antifungal effectiveness, especially against MRSA.
- The nanoparticles were found to decrease cell viability in MCF-7 cancer cells, indicating potential cytotoxic effects, and they also led to oxidative stress through reduced glutathione levels and increased reactive oxygen species, suggesting their usefulness in medical and food applications.
Article Abstract
Current exanimation reports, green fabrication of silver doped TiO nanoparticles (Ag/TiO) using aqueous extract of as bio-reductant and assess its potential as antimicrobial and anticancer agent. The obtained spherical Ag/TiO were characterized by various analytical techniques including FTIR, (XRD), (FE-SEM EDS), and (TEM). Synthesized Ag/TiO demonstrated broad spectrum antibacterial and anticandidal activity. The order of antimicrobial activity was found to be > > MRSA > . In addition, cytotoxicity and oxidative stress of Ag/TiO nanoparticles in (MCF-7) cells was also investigated. Outcomes of MTT assay showed concentration dependent reduction in cell viability. Further, synthesized NPs reduced the level of glutathione, induced ROS generation and lipid peroxidation in the treated cells. Therefore, it is envisaged that these spherical nanoparticles may be exploited in drug delivery, pharmaceutical, and food industry.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904800 | PMC |
| http://dx.doi.org/10.1016/j.sjbs.2019.09.005 | DOI Listing |
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