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Safety and Efficacy of Jenacid® Herbal Product Against Indomethacin-Induced Ulcers in Albino Wistar Rats.
Cureus
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Department of Pharmacology and Toxicology, Kampala International University Western Campus, Bushenyi, UGA.
Background: Jenacid Herbal Product (JHP) used for treating peptic ulcer disease in Uganda, sold over the counter, is approved by the National Drug Authority as a Traditional Herbal Product number THP 482. There have been no published studies on its safety and efficacy.
Objective: This study aimed to assess potential acute and subacute toxicity as well as the efficacy of JHP.
Tadalafil pretreatment attenuates doxorubicin-induced hepatorenal toxicity by modulating oxidative stress and inflammation in Wistar rats.
Toxicol Rep
December 2024
Department of Oral Pathology and Medicine, Faculty of Dentistry, Lagos State University College of Medicine, 1-5 Oba Akinjobi Way, G.R.A., Ikeja, Lagos State, Nigeria.
Doxorubicin (DOX) is a widely used anticancer agent, but its clinical application is limited by significant off-target hepatorenal toxicity. Tadalafil (TAD), a selective phosphodiesterase-5 inhibitor used mainly for erectile dysfunction and pulmonary arterial hypertension, has shown potential in reducing oxidative stress. This study investigated TAD's chemoprotective effects and underlying mechanisms in DOX-induced hepatorenal toxicity in rats over 12 days.
View Article and Find Full Text PDFIn vivo cardiovascular profile of ryanodine receptor 2 inhibitor M201-A: Utility as an anti-atrial fibrillatory drug for patients suffering from heart failure with preserved ejection fraction.
J Pharmacol Sci
November 2024
Department of Pharmacology, Faculty of Medicine, Toho University, 5-21-16 Omori-nishi, Ota-ku, Tokyo, 143-8540, Japan; Kazuya Yokoyama Cancer Research Institute, 1-4-8 Ueno, Taito-ku, Tokyo, 110-0005, Japan. Electronic address:
Atrial fibrillation (AF) and heart failure with preserved ejection fraction (HFpEF) often coexist; however, clinically available anti-AF drugs can exacerbate symptoms of HFpEF. M201-A suppressed ryanodine receptor-mediated diastolic Ca leakage, possibly inhibiting common pathological processes toward AF and HFpEF. To bridge the basic information to clinical practice, we assessed its cardiohemodynamic, anti-AF and ventricular proarrhythmic profile using halothane-anesthetized dogs (n = 4).
View Article and Find Full Text PDFAnalysis of cardiohemodynamic and electrophysiological effects of morphine along with its toxicokinetic profile using the halothane-anesthetized dogs.
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Department of Pharmacology, Faculty of Medicine, Toho University.
Although morphine has been used for treatment-resistant dyspnea in end-stage heart failure patients, information on its cardiovascular safety profile remains limited. Morphine was intravenously administered to halothane-anesthetized dogs (n=4) in doses of 0.1, 1 and 10 mg/kg/10 min with 20 min of observation period.
View Article and Find Full Text PDFThe halothane era in pediatric anesthesia: The convergence of a cardiac depressant anesthetic with the immature myocardium of infancy.
Paediatr Anaesth
July 2024
Department of Anesthesiology, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, Colorado, USA.
Article Synopsis
- Halothane was the primary inhalational anesthetic for children from the late 1950s until the late 1990s, but it posed significant risks, particularly for neonates and infants, due to its negative effects on heart function.
- In neonates, halothane caused increased rates of hypotension and cardiac arrest because their hearts are still developing and are more sensitive to the drug compared to older children.
- By the late 1990s, newer anesthetics like sevoflurane, which had a safer profile for pediatric patients, led to halothane's decline and eventual removal from pediatric anesthesia in North America.
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