Breast cancer treatment in the elderly: Do treatment plans that do not conform to NCCN recommendations lead to worse outcomes?

Am J Surg

Department of Surgery, The University of Kansas School of Medicine-Wichita, Wichita, KS, USA; Ascension Via Christi Clinic, Wichita, KS, USA. Electronic address:

Published: August 2020

Background: Aging remains one of the greatest risk factors for development of new breast cancer with more than 30% of breast cancers occurring after the age of 75. Elderly women have been found to not conform with all aspects of treatment recommendations. Our study compared outcomes of elderly breast cancer patients whose treatment did or did not conform to NCCN guidelines.

Methods: A retrospective review was conducted of breast cancer patients over the age of 70. Comparisons were made between patients whose treatment did or did not conform to NCCN guidelines for recurrence, metastatic disease, and breast cancer related deaths.

Results: Patients whose treatment did not conform to NCCN guidelines were older (80.5 vs. 77.7 years, P = 0.001). No significant difference was seen between groups for tumor size, breast cancer type, or nodal status; however, more nonconforming women were ER/PR positive (90.3% vs. 76.6%, P = 0.020). There was no significant difference in local recurrence, metastatic disease, or breast cancer related deaths.

Conclusions: Women whose treatment did not conform to NCCN guidelines were not associated with worse outcomes.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.amjsurg.2019.12.007DOI Listing

Publication Analysis

Top Keywords

breast cancer
28
conform nccn
20
treatment conform
16
patients treatment
12
nccn guidelines
12
breast
8
cancer patients
8
recurrence metastatic
8
metastatic disease
8
disease breast
8

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!