AI Article Synopsis
- The study highlights the difficulty primary care doctors face in identifying children at risk of severe neurological complications from mild hand, foot and mouth disease (HFMD).
- From January 2012 to December 2015, a case-control study involved 225 children with severe HFMD and 492 matched controls, using various statistical analyses to assess risk factors.
- The findings identified key independent risk factors for severe HFMD, including a peak body temperature over 37.5℃, fever lasting more than 3 days, lethargy, and infection with enterovirus 71 (EV71).
Article Abstract
Introduction: In clinical perspectives, how to distinguish a small proportion of children at risk of developing neurological complications from a large number of children with mild symptoms still remains a challenge for primary care doctors.
Methodology: From January 2012 to December 2015, 225 cases with severe hand, foot and mouth disease (HFMD) matched with 492 controls were enrolled in the age-matched, case-control study. Continuous variables were examined by univariate analysis using a chi-squared or Fisher's exact test, and categorical variables were reported by relative risks (odd's ratio). Multivariate logistic regression was used to analyze the independent risk factors for severe HFMD.
Results: Peak body temperature over 37.5℃，total duration of fever over 3 days, lethargy, enterovirus 71 (EV71) infection were independent risk factors for severe HFMD.
Conclusions: Peak body temperature over 37.5℃，total duration of fever over 3 days, lethargy, EV71 infection were independent risk factors for severe HFMD.
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| http://dx.doi.org/10.3855/jidc.9845 | DOI Listing |
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