Departamento de Física, FFCLRP, Universidade de São Paulo, Ribeirão Preto, SP 14040-901, Brazil.
Published: August 2021
AI Article Synopsis
Article Abstract
Epilepsy has been a central topic in computational neuroscience, and in silico models have shown to be excellent tools to integrate and evaluate findings from animal and clinical settings. Among the different languages and tools for computational modeling development, NEURON stands out as one of the most used and mature neurosimulators. However, despite the vast quantity of models developed with NEURON, a fragmentation problem is evident in the great majority of models related to the same type of cell or cell properties. This fragmentation causes a lack of interoperability between the models because of differences in parameters. The problem is not related to the neurosimulator, which is prepared to reuse elements of other models, but related to decisions made during the model development, when it is not uncommon to adjust parameter values according to the necessities of the study. Here, this problem is presented by studying computational models related to temporal lobe epilepsy and the definitions of hippocampal CA1 pyramidal cells. The current assessment aims to highlight the implications of fragmentation for reliable modeling and the need to adopt a framework that allows a better interoperability between different models. This article is part of the Special Issue "NEWroscience 2018".
Microplastics (MPs) are a growing problem worldwide. Soils are long-term storage sinks of MPs because of the many pathways they enter the soil and their long degradation period. Knowing how MPs influence soil organisms, the effects of organisms on the fate of MPs, and what this means for soil additions, losses, transformations, and translocations is paramount.
In recent years, energy correlators have emerged as a powerful tool to explore the field theoretic structure of strong interactions at particle colliders. In this Letter we initiate a novel study of the nonperturbative power corrections to the projected N-point energy correlators in the limit where the angle between the detectors is small. Using the light-ray operator product expansion as a guiding principle, we derive the power corrections in terms of two nonperturbative quantities describing the fragmentation of quarks and gluons.
Introduction: Children with cerebral palsy (CP) are treated by well-co-ordinated multi-disciplinary neuromuscular teams. With a comprehensive multidisciplinary team, co-ordinating the transfer to adult care is a challenge. Orthopaedic care becomes fragmented as patients transfer from paediatric orthopaedic surgeons with training in multi-joint neuromuscular conditions (NMCs), to adult orthopaedic surgeons where this expertise rarely exists.
Beta-lactam antibiotics are the most applied antimicrobials in human and veterinarian health care. Hence, beta-lactam resistance is a major health problem. Gene amplification of AmpC beta-lactamase is a main contributor to β-lactam resistance in .
Corneal alkali burns persist as a significant challenge in our field, often leading to a prolonged treatment course with various sight-threatening problems. This work, of utmost importance, aimed to apply the photo-tissue bonding technique (PTB) to weld the amniotic membrane (AM) to the corneal surface versus an amniotic membrane graft (AMG) and explore its safety in saving corneal protein against alkali burn.Methods Twenty-seven rabbits with an induced corneal ulcer using 1 mol/L NaOH solution.
