AI Article Synopsis
- * A study involving 56 children found that high-dose intravenous methylprednisolone (IVMP) led to improvements in visual acuity and reduced inflammation within 3 months.
- * Children receiving more than 3 doses of IVMP showed fewer relapses and complications compared to those who received just 1 dose, highlighting the potential benefits of this treatment strategy, though further research is needed.
Article Abstract
Non-infectious uveitis is associated with visual impairment and blindness. Non-biologic treatment for non-infectious uveitis is not based on strong evidence. A retrospective chart review was conducted to investigate treatment response to high-dose intravenous methylprednisolone (IVMP) in children with non-infectious uveitis. Fifty-six patients (93 eyes affected) were included. In 29% uveitis was associated with juvenile idiopathic arthritis. Uveitis predominately affected the anterior segment, was bilateral and recurrent. Complications were common and included visual loss, synechiae, cataract and/or retinal lesions. Patients received up to 5 IVMP at monthly intervals. Visual acuity improved at 3 and 6 months. Anterior chamber cells, synechiae, keratic precipitates, papillary and/or macular edema improved at 3 months. Children treated with ≥3 IVMP (vs 1 IVMP) experienced trends towards fewer relapses, fewer cataracts and less frequently required treatment with biologic agents. High-dose IVMP induce rapid improvement in children with non-infectious uveitis. Prospective randomized trials are required to confirm results.
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| http://dx.doi.org/10.1016/j.clim.2019.108327 | DOI Listing |
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