AI Article Synopsis
- Polyphenol-rich foods might help prevent diseases caused by oxidative stress and have antibacterial properties.
- The study analyzed wild L. fruit from southeast Italy for its antimicrobial activity and antioxidant capacity, finding high levels of beneficial compounds like rutin and 4-hydroxybenzoic acid.
- PSF extract showed effective antimicrobial action against harmful bacteria and exhibited strong antioxidant effects in both cell tests and oxidative stress-induced rat models, suggesting its potential use in health and food industries.
Article Abstract
Polyphenol-rich foods could have a pivotal function in the prevention of oxidative stress-based pathologies and antibacterial action. The purpose of this study was to investigate the in vitro antimicrobial activity, as well as the in vitro and in vivo antioxidant capacities of wild L. fruit (PSF) from the southeast regions of Italy The total phenolic content (TPC) was quantified, and the single polyphenols were analyzed by HPLC-DAD, showing high rutin and 4-hydroxybenzoic acid levels, followed by gallic and trans-sinapic acids. PSF extract demonstrated antimicrobial activity against some potentially pathogenic Gram-negative and Gram-positive bacteria. Besides, we investigated the cellular antioxidant activity (CAA) and the hemolysis inhibition of PSF extract on human erythrocytes, evidencing both a good antioxidant power and a marked hemolysis inhibition. Furthermore, an experiment with oxidative stress-induced rats treated with a high-fat diet (HFD) and a low dose of streptozotocin (STZ) demonstrated that PSF has a dose-dependent antioxidant capacity both in liver and in brain. In conclusion, the wild Italian L. fruit could be considered a potentially useful material for both nutraceutical and food industries because of its antioxidant and antimicrobial effects.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023410 | PMC |
| http://dx.doi.org/10.3390/foods9010005 | DOI Listing |
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