AI Article Synopsis
- Pregnancy-associated malaria is a less researched issue in Latin America compared to Africa, where most studies focus on its effects on pregnancy.
- Infections by Plasmodium spp can lead to altered immune responses and changes in the placental environment, impacting fetal and neonatal development.
- This review aims to explore how Plasmodium spp affects the host's immune response and the potential negative outcomes for both mothers and their newborns.
Article Abstract
Pregnancy-associated malaria is an understudied event in Latin America. Most works about malaria in pregnancy have been conducted in Africa. These studies indicate that the infection generates immune response modulation and alterations in the placental environment, key factors for the proper development of the fetus and neonate. Immunity against Plasmodium spp is complex since involves several factors that increase the possible infection outcomes. One of these immunological outcomes is the immune response modulation towards a regulatory profile, which is advantageous for the persistence of the parasite in the host; additionally, it could generate adverse events in the general immune response of infected individuals. The objective of this review is to address the Plasmodium spp mechanisms of modulation in the host immune response and expose the consequences of malarial infections in the mother-neonate context.
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| http://dx.doi.org/10.4067/S0716-10182019000300341 | DOI Listing |
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