AI Article Synopsis
- The study identifies miR-499-5p as a key regulator of Stat-3 signaling involved in gastric cancer cell survival and metastasis.
- It reveals that miR-499-5p is significantly elevated in the SGC-7901 gastric cancer cell line and promotes cell growth and invasion.
- The research highlights the interaction between miR-499-5p, its target PDCD4, and the STAT3 signaling pathway as critical to gastric cancer progression, suggesting potential therapeutic implications.
Article Abstract
The present study explored a new downstream regulator of Stat-3 signaling, miR-499-5p and its target gene programmed cell death 4 (PDCD4) in cell survival and metastasis of gastric cancer. Our results showed that miR-499-5p is significantly upregulated in human gastric cancer cell line SGC-7901. We further demonstrated that miR-499-5p promotes gastric cancer cell proliferation and invasion in vitro. Mechanistically, we demonstrated that upregulation of miR-499-5p expression associated with inhibition of PDCD4; STAT3 transcriptional activation by IL-6 is crucial for the upregulation of miR-499-5p expression. These results indicate that the STAT3-miR-499-5p-PDCD4 signaling axis plays an important role in gastric cancer progression and a potentially therapeutic target for gastric cancer treatment.
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| http://dx.doi.org/10.1002/kjm2.12159 | DOI Listing |
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