Correction for 'A folate-conjugated platinum porphyrin complex as a new cancer-targeting photosensitizer for photodynamic therapy' by Mengqian Yang et al., Org. Biomol. Chem., 2019, 17, 5367-5374.
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Correction: A folate-conjugated platinum porphyrin complex as a new cancer-targeting photosensitizer for photodynamic therapy.
Org Biomol Chem
January 2020
Key Laboratory for Green Chemical Process of the Ministry of Education, School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, Wuhan, 430205, P. R. China.
Correction for 'A folate-conjugated platinum porphyrin complex as a new cancer-targeting photosensitizer for photodynamic therapy' by Mengqian Yang et al., Org. Biomol.
View Article and Find Full Text PDFA step-wise synthetic approach is necessary to access γ-conjugates of folate: folate-conjugated prodigiosenes.
RSC Adv
May 2019
Department of Chemistry, Dalhousie University PO Box 15000 Halifax NS, B3H 4R2 Canada +1-902-494-3305.
Despite the vast literature that describes reacting folic acid with a pharmacophore, this route is ineffective in providing the correct regioisomer of the resulting conjugate. We herein present a step-wise route to the preparation of nine folate conjugates of the tripyrrolic prodigiosene skeleton. The strict requirement for step-wise construction of the folate core is demonstrated, so as to achieve conjugation at only the desired γ-carboxylic acid and thus maintain the α-carboxylic site for folate receptor (FRα) recognition.
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