AI Article Synopsis
- Materials with electron spin can enhance relaxation times in MRI, and gadolinium (Gd) is commonly used but has potential side effects.
- To find safer alternatives, researchers synthesized seven NO radicals with a specific framework and various substituents as metal-free contrast agents.
- They established a relationship between water-proton relaxivity, reactivity with ascorbic acid, and the spin density of the NO oxygen atom, aiding in the design of effective metal-free MRI agents.
Article Abstract
Materials possessing electron spin can shorten the relaxation times in magnetic resonance imaging (MRI). For example, gadolinium (Gd) complexes with seven f-orbital electrons are widely used as contrast agents in clinical applications. However, Gd has severe potential side effects, and thus metal-free alternatives are needed. Toward this end, we synthesized seven NO radicals consisting of a dioxa-azaspiro[4.5]decane framework having various substituents, (X = methyl, ethyl, -propyl, -propyl, vinyl, phenyl, and 2-pyridyl), that functioned as metal-free MRI contrast agents. The relationship between (i) water-proton relaxivity and log and (ii) reactivity for ascorbic acid and the spin density of the NO oxygen atom were established, which provided a basis for the rational design of practical metal-free contrast agents.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906943 | PMC |
| http://dx.doi.org/10.1021/acsomega.9b03003 | DOI Listing |
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