Rational use of antimicrobials in the treatment of upper airway infections.

J Pediatr (Rio J)

Universidad de Murcia, Hospital Clínico Universitario Virgen de la Arrixaca (HCUVA), Respiratory Medicine and Allergy Units, Murcia, Spain; Instituto de Pesquisa em Biomedicina de Murcia (IMIB), Murcia, Spain; Rede ARADyAL, Madrid, Spain. Electronic address:

Published: January 2021

Objective: To analyze the main cause of the irresponsible use of antibiotics at the pediatric level in a very frequent, usually self-limited, and typically viral condition: upper airway respiratory infections.

Sources: Different databases were searched using specific terms related to resistance to antibiotics, upper airway respiratory infections, and pediatrics patients.

Summary Of The Findings: Effectiveness varies depending on the place, the form of intervention, and the resources used. Multiple interventions appear to be more effective. The foundations of treatment are training in technical aspects and in communication skills for the prescribers, and having enough time for each patient; and training through the health clinic and the media for patients/parents. Deferred prescription and the use of rapid diagnostic tests in the primary care setting have been shown to be effective. A fluid relationship based on trust between clinicians and parents/guardians is one of the keystones.

Conclusions: Any project that seeks to be totally effective must include a health authority, which in addition to helping implement these measures, has the firm intention of drastically reducing the use of antibiotics in animals and in the environment, as well as favoring research into new antimicrobials.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9432007PMC
http://dx.doi.org/10.1016/j.jped.2019.11.001DOI Listing

Publication Analysis

Top Keywords

upper airway
12
airway respiratory
8
rational antimicrobials
4
antimicrobials treatment
4
treatment upper
4
airway infections
4
infections objective
4
objective analyze
4
analyze main
4
main irresponsible
4

Similar Publications

The lack of a robust system to reproducibly propagate HRV-C, a family of viruses refractory to cultivation in standard cell lines, has substantially hindered our understanding of this common respiratory pathogen. We sought to develop an organoid-based system to reproducibly propagate HRV-C, and characterize virus-host interaction using respiratory organoids. We demonstrate that airway organoids sustain serial virus passage with the aid of CYT387-mediated immunosuppression, whereas nasal organoids that more closely simulate the upper airway achieve this without any intervention.

View Article and Find Full Text PDF

Modeling aerosol dynamics in the airways is challenging, and most modern personalized tools consider only a single inhalation maneuver through less than 10% of the total lung volume. Here, we present an modeling pipeline to produce a device that preserves patient-specific upper airways while approximating deeper airways, capable of achieving total lung volumes over 7 liters. The modular system, called TIDAL, includes tunable inhalation and exhalation breathing capabilities with resting flow rates up to 30 liters per minute.

View Article and Find Full Text PDF

Neurodevelopmental impairment in children with Robin sequence: A systematic review and meta-analysis.

Early Hum Dev

December 2024

Perth Children's Hospital, Perth, Western Australia, Australia; University of Western Australia, Perth, Western Australia, Australia. Electronic address:

Objective: To estimate the global prevalence of neurodevelopmental impairment in children with Robin sequence (RS) at one year or more of age.

Study Design: Electronic databases such as PubMed, Embase, CINAHL, APA PsycInfo, Emcare, MedNAR and Cochrane library were searched systematically from inception to 31st May 2024. Studies reporting on the neurodevelopmental (global, cognitive, or motor) outcomes in children with RS were included.

View Article and Find Full Text PDF

Objectives: To compare the variations in the upper airway of children with skeletal Class II mandibular retrognathism treated with van Beek Headgear-Activator (vBHGA) and Twin-Block (TB) appliances.

Materials And Methods: 40 children were involved in this retrospective study and divided into two intervention groups: the vBHGA group and the TB group, each comprising 20 individuals with an average age of 11.13 years.

View Article and Find Full Text PDF

Introduction: Moderate-to-severe obstructive sleep apnea (OSA) affects a large segment of the US population and is characterized by repetitive and reversible obstruction of the upper airway during sleep. Untreated OSA is associated with increased incidence of heart attack, stroke, and motor vehicle accidents due to sleepiness. Continuous positive airway pressure is often prescribed, but most patients with OSA are nonadherent.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!