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Abl kinases regulate FGF signaling independent of Crk phosphorylation to prevent Peters anomaly.
bioRxiv
October 2024
Departments of Ophthalmology, Pathology and Cell Biology, Columbia University, New York, NY 10032, USA.
Article Synopsis
- Peters anomaly, a leading cause of congenital corneal opacity, is linked to corneal-lenticular adhesion and is tied to unidentified mutations and a complex disease mechanism.
- Abl kinases have been discovered as key regulators of FGF signaling, with their genetic deletion allowing lens formation even when FGF is missing, and their role appears independent of traditional ERK signaling pathways.
- The study suggests that targeting the Ptpn12-p130Cas pathway, which is influenced by Abl kinases, could offer therapeutic possibilities for addressing Peters anomaly by improving lens vesicle separation dynamics.
Peters anomaly: An overview.
Taiwan J Ophthalmol
October 2023
Cornea and Anterior Segment Service, Shantilal Shanghvi Cornea Institute, L V Prasad Eye Institute, Hyderabad, Telangana, India.
Peters anomaly (PA) is a rare, often bilateral, congenital corneal opacity, usually with a sporadic inheritance pattern, characterized by corneal opacities and irido-corneal or lenticular-corneal adhesions with a defect in the Descemet's membrane, occurring due to anterior segment dysgenesis during fetal development. Due to other ocular and systemic comorbidities, a team comprising pediatric cornea, glaucoma, and strabismus specialists in addition to a pediatrician and geneticist is necessary for the appropriate management of these children. Since the outcome of pediatric penetrating keratoplasty is variable and has a higher chance of failure when accompanied by additional procedures, such as lensectomy and vitrectomy, minimally invasive alternatives are increasingly being offered to these patients.
View Article and Find Full Text PDFMining and analysis of adverse event signals of Cariprazine based on the real-world data of FAERS database.
J Affect Disord
February 2024
Department of Psychology, The Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, China. Electronic address:
Objective: This study aims to analyze the adverse events (AEs) of Cariprazine based on the FAERS database, providing evidence for its safety surveillance.
Methods: For signal quantification of Cariprazine-related AEs, we used disproportionality analysis including the Ratio of Odds Ratio (ROR), Proportional Reporting Ratio (PRR), Bayesian Confidence Propagation Neural Network (BCPNN), and Multi-Item Gamma Poisson Shrinker (MGPS) algorithms.
Results: We selected Cariprazine-related AE reports from the FAERS database from the fourth quarter of 2015 to the first quarter of 2023, and performed a detailed data analysis.
Juvenile ocular abnormalities in a litter of black-footed ferrets.
Vet Ophthalmol
March 2024
Hope Advanced Veterinary Center, Vienna, Virginia, USA.
Objective: To describe the clinical and histopathological features of ocular abnormalities noted in a litter of black-footed ferrets (Mustela nigripes), including corneal opacification, cataracts, persistent pupillary membranes, microphthalmia, symblepharon and anterior segment malformation.
Animals Studied: A litter of eight black-footed ferrets examined at 10 weeks old with a history of ophthalmia neonatorum first noted at 7 days old and histopathological examination of three globes from three ferrets of the same litter between 5 and 7 months old following routine subconjunctival enucleation.
Procedures: Due to the fractious nature of black-footed ferrets, slit-lamp biomicroscopic examination was performed under general isoflurane anesthesia at 10 weeks of age.
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