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Analyzing Apomorphine-Mediated Effects in a Cell Model for Parkinson's Disease with Partial Least Squares Structure Equation Modeling.
J Comput Biol
August 2020
Department of Biomolecular and Chemical Engineering, DongYang University, Yeongju, Korea.
Baclofen reverses the reduction in prepulse inhibition of the acoustic startle response induced by dizocilpine, but not by apomorphine.
Psychopharmacology (Berl)
January 2004
Department of Neuroscience B.B. Brodie, Center of Excellence Neurobiology of Dependence, University of Cagliari, Cittadella Universitaria, SS 554 Km 4,500, 09042 Monserrato (CA), Italy.
Rationale: Since baclofen, the prototypical GABA(B) receptor agonist, is known to reduce the activity of dopaminergic mesolimbic neurons, a putative antipsychotic property of this compound has been suggested, but the evidence for this is still controversial.
Objectives: The aim of the present study was to elucidate the effects of baclofen on the prepulse inhibition (PPI) of the acoustic startle response (ASR), a behavioral paradigm considered to be one of the most powerful tools for the evaluation of sensorimotor gating and for the screening of antipsychotics.
Methods: We tested the effects of baclofen (1.
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