An efficient visible-light-induced -selective C(sp)-H difluoroalkylation of diverse electron-deficient (hetero)aromatic carbonyls (aldehydes and ketones) at ambient temperature has been developed by employing Ir(ppy) as the catalyst and 1,10-phenanthroline as the additive. This protocol was highlighted by its wide substrate scope, high regioselectivity, low catalyst usage, and operational simplicity.
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| http://dx.doi.org/10.1021/acs.orglett.9b03923 | DOI Listing |
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