Objective: Many studies have focused on correlations between forkhead box protein C2 (FOXC2) and various tumors but discrepant results have been reported. Thus, we conducted this meta-analysis to assess the prognostic role of FOXC2 in tumors.
Methods: Four electronic databases (PubMed, Embase, Web of Science, and SinoMed) were screened through September 2019.
Results: The final analysis included 15 reports and 2115 patients; results suggested that cancer patients with FOXC2 had worse overall survival (hazard ratio 2.14, 95% confidence interval (CI) 1.74-2.64), cancer-specific survival (hazard ratio 2.65, 95% CI 1.44-4.89), and disease-free survival (hazard ratio 1.93, 95% CI 1.49-2.50) than patients lacking FOXC2.
Conclusions: The presence of FOXC2 was associated with poor survival in cancer patients. FOXC2 could be a promising prognostic marker in the future.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7607161 | PMC |
| http://dx.doi.org/10.1177/0300060519891648 | DOI Listing |
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