Aim: This study aimed to investigate the impact of rabbit serum on skin wound healing with the help of histological examination.
Materials And Methods: A total of ten indigenous rabbits were used in this study. The animals were divided into two groups: control and serum- treated. The histological assessment was done with a paraffin embedding technique and the histological sections were stained with H&E stain.
Results: Severe infiltration of polymorphonuclear leukocytes with severe fibrin deposits were seen in serum treated group at 2 days post-injury; at 7 days post-injury the changes revealed moderate fibroplasia, fibrin deposit and severe infiltration of both mononuclear and polymorphonuclear leukocytes; at 14 days post-injury, there were marked epithelization and dermal deposition of collagen fibers; and at 21 days post-injury, the epidermis completed epithelization and the dermis showed neither fibroplasia nor infiltration of mononuclear and polymorphonuclear leukocytes.
Conclusion: The results indicated that rabbit's serum can prevent wound infection, accelerate epithelialization and cutaneous regeneration with less granulation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868260 | PMC |
| http://dx.doi.org/10.14202/vetworld.2019.1650-1656 | DOI Listing |
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