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Surgical management of a huge mediastinal mature teratoma in a 2-year-old girl: a case report.
Gen Thorac Cardiovasc Surg Cases
December 2024
Department of Surgery II, Faculty of Medicine, Yamagata University, 2-2-2 Iida-Nishi, Yamagata, Japan.
Background: Mature teratomas are benign cystic tumors that are most commonly asymptomatic. However, in some cases, mediastinal teratomas rupture the lungs and mediastinum with potentially fatal outcomes. Herein, we report a case of a large mediastinal mature teratoma that expanded to the entire left hemithorax in a child with common cold-like symptoms.
View Article and Find Full Text PDFThe Potential of Hair-Follicle-Associated Pluripotent (HAP) Stem Cells for Regenerative Medicine.
Methods Mol Biol
December 2024
AntiCancer, Inc., San Diego, CA, USA.
Nestin-expressing hair-follicle-associated pluripotent (HAP) stem cells from mouse and human have been shown to differentiate into neurons, glia, keratinocytes, smooth muscle cells, cardiac muscle cells, and melanocytes in vitro. HAP stem cells have promoted the recovery of peripheral nerve and spinal cord injuries in mouse models by differentiating into glial fibrillary acidic protein (GFAP)-positive Schwann cells. HAP stem cells enclosed on polyvinylidene fluoride membranes (PFM) were transplanted into the severed thoracic spinal cord of nude mice.
View Article and Find Full Text PDFReinvesting the cellular properties of human amniotic epithelial cells and their therapeutic innovations.
Front Immunol
October 2024
Institute for Regenerative Medicine, Medical Innovation Center and State Key Laboratory of Cardiology, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China.
Article Synopsis
- Human amniotic epithelial cells (hAECs) are promising for therapy due to their low immunogenicity, ability to modulate immune responses, and lack of tumor formation.
- Despite their potential, challenges such as unclear cell properties, unclear mechanisms of action in therapies, and limited cell proliferation hinder large-scale clinical applications.
- The review highlights hAECs' lineage development, characteristics, cultivation methods, current clinical status, advantages, limitations, and future prospects in cell therapy.
Managing Limbal Dermoids in Patients with Goldenhar Syndrome: A Case Series.
Rom J Ophthalmol
October 2024
ENT Department, Military Hospital, Jammu, J&K, India.
Objective: To investigate the clinical characteristics, associated systemic features, and management outcomes of patients with limbal dermoids diagnosed with Goldenhar syndrome.
Methods: This case series included patients from the eye outpatient department, diagnosed with Goldenhar syndrome based on systemic evaluation. Demographic data, ophthalmological assessments, and systemic evaluations were recorded.
Six induced pluripotent stem cell lines from fibroblasts of individuals with CLN3-related conditions.
Stem Cell Res
December 2024
Unit on Cellular Stress in Development and Diseases, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA. Electronic address:
Primary fibroblasts from six individuals with CLN3-related conditions were used to generate induced pluripotent stem cell (iPSC) lines CHDTRi001-B, CHDTRi002-B, CHDTRi003-A, CHDTRi004-B, CHDTRi005-A, and CHDTRi006-E through the expression of four reprogramming factors: human OCT3/4, KLF4, SOX2, and c-MYC. The iPSC lines were characterized to confirm their pluripotency via immunocytochemistry, flow cytometry, and teratoma formation. Genomic stability, cell line identity, and CLN3 genotype were confirmed.
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