AI Article Synopsis
- The analysis of complex mixtures poses challenges, particularly when dealing with sparse fluorine atoms in the species being studied.
- The FESTA methodology allows for efficient extraction of NMR spectra from these fluorine-containing mixtures.
- The new MODO-FESTA approach, which uses a modulated spin echo for initial excitation, simplifies the process and offers greater sensitivity compared to the existing SRI-FESTA method.
Article Abstract
The analysis of complex mixtures is an important but often intractable problem. When species contain sparse fluorine atoms, NMR spectra of fluorine-containing spin systems can be efficiently extracted from an intact mixture using the recently proposed FESTA (Fluorine-Edited Selective TOCSY Acquisition) methodology. Here an alternative approach to the existing selective reverse INEPT FESTA (SRI-FESTA) experiment is described, based on the use of a modulated spin echo for the initial excitation. MODO-FESTA (modulated echo FESTA) is simpler and has a significant sensitivity advantage over SRI-FESTA. Comparisons are presented of the relative sensitivity and spectral purity of the two types of methods.
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| http://dx.doi.org/10.1021/acs.analchem.9b04924 | DOI Listing |
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