AI Article Synopsis
- Spermiogenesis, the final phase of sperm development, involves autophagy, a process where cells recycle their components to maintain functionality.
- During this stage, the sperm cell forms the acrosome and sheds most of its cytoplasm to ensure efficiency and mobility.
- The review aims to compile current research on how autophagy affects the health and function of mature male gametes and how various environmental factors may impact this process.
Article Abstract
Spermiogenesis, the ultimate stage of spermatogenesis, is a process involving autophagy. At this stage, the acrosome is generated by vesicular fusion and most of the cytoplasm disappears. Autophagy, literally "eating oneself", allowing the elimination and replacement of proteins and nonfunctional organelles, ensures the recycling of cellular constituents and is a highly conserved cellular mechanism within eukaryotic cells. The machinery of autophagy is present in the spermatozoon, regulating the vitality and mobility of the cells. The environmental and behavioral impact on autophagy and the consequences on spermatogenesis are beginning to be studied. The purpose of this review is to synthesize current knowledge about autophagy in the mature male gamete.
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| http://dx.doi.org/10.1051/medsci/2019172 | DOI Listing |
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