AI Article Synopsis

  • The study aimed to evaluate the blood transfusion practices for sickle cell disease patients in the UK and Republic of Ireland, focusing on the resources available, types of transfusions, and adherence to standards.
  • It conducted a retrospective audit involving 84 hospitals and analyzed 1,290 transfusion cases from January to July 2014, revealing that a majority of transfusions were for patients with HbSS and that there was a significant demand for Rh CE negative blood.
  • Conclusions highlighted gaps in clinical management protocols, training for staff, and network arrangements, along with notable differences in transfusion practices between children and adults.

Article Abstract

Objectives: To determine the organisational resources in place; what blood was being transfused, why, how, where, when and by whom; whether laboratory support and policies met standards for patients with sickle cell disease (SCD).

Background: SCD affects 14 000 people in the United Kingdom (UK). Standards and guidelines do not cover all aspects of transfusion in SCD and there are no data on their use; people may become very sick without warning presenting to non-specialist hospitals; blood services are increasingly supplying units for transfusion in SCD with little data on their use.

Methods: A retrospective audit of transfusion services/practice for people with SCD who had received a transfusion in January-July 2014 in participating hospitals in the UK and Republic of Ireland (ROI).

Results: Eighty-four hospitals submitted 1290 cases, 75% of cases came from 18 hospitals submitting 25 or more cases. Transfusions (91.2% [1164/1276]) were administered to patients with HbSS, 60% (732/1227) of patients needed Rh CE negative blood. Transfusion episodes (4528) were recorded, of which 84% were elective. Stroke prevention accounted for 42% of all transfusions; adults received 56% of transfusions of which 50% were automated red cell exchange (RCE), children received 44% of transfusions of which 87% were simple transfusions.

Conclusions: There was a paucity of appropriate clinical management protocols, adequately trained staff and network arrangements. The high numbers of children being transfused, disparity in transfusion modality between children and adults and the high frequency of the CE negative Rh phenotype were noted.

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Source
http://dx.doi.org/10.1111/tme.12655DOI Listing

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