The high demand for cosmetics has had a great impact on the development of innovative products in the cosmetic industry. The availability of raw materials has become a common problem in the cosmetic industry. Materials from nature can act as alternative sources, such as . Several studies have shown the potential of as an antioxidant and skin lightening agent. The objectives of the present study were to develop and optimize a green ultrasound-assisted deep eutectic solvent extraction of . Eleven deep eutectic solvents were evaluated based on extraction efficiency parameters; that is, flavonoid and anthocyanin yields; the antioxidant and tyrosinase inhibitory activities of the extracts. The combination of choline chloride and propylene glycol (1:1) was shown to be the optimal deep eutectic solvent for extraction. The extraction parameters of temperature, extraction time, and solid-to-liquid ratio were also optimized using response surface methodology. The total flavonoid compound obtained was 33 mg quercetin equivalent/g dried sample under the optimum extraction condition (extraction time of 5 min, temperature of 57 °C, solid-to-liquid ratio of 0.02 g/mL). In sum, this work demonstrates the potential of natural deep eutectic solvent as an organic solvent replacement to obtain high quality extract, which is a potential new source of skin-lightening cosmetic materials.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895584 | PMC |
| http://dx.doi.org/10.1016/j.heliyon.2019.e02950 | DOI Listing |
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