The assessment of the environmental fate and (eco)toxicological effects of pesticide compounds is of crucial importance. The present review is focused on Quantitative Structure-Property Relationships (QSPR) applications on three environmentally relevant physicochemical properties of pesticides, which can be used for assessing their environmental partition and transport, as well as exposure potential namely water solubility, octanol-water partition coefficient and vapour pressure. This article revises various interesting QSPR applications with special emphasis on studies developed during the 2009-2019 period.
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http://dx.doi.org/10.1080/1062936X.2019.1699602 | DOI Listing |
Mol Pharm
January 2025
Department of Pharmacy, National and Kapodistrian University of Athens, Zografou 15771, Greece.
The simulation of antral conditions for estimating drug apparent equilibrium solubility after a high-calorie, high-fat meal is challenging. In this study, (1) we measured the apparent equilibrium solubility of two model lipophilic drugs, ketoconazole and danazol, in antral aspirates collected at various time points after a minced high-calorie, high-fat meal and a glass of water 30 min after initiation of meal administration, and we designated one point estimate for ketoconazole and one point estimate for danazol; (2) we evaluated the usefulness of FeSSGF-V2 and FEDGAS pH = 3 in reproducing the two point estimates; (3) we evaluated potential compositions of FeSSGF-V3 that simulate the pH, the buffer capacity toward both less acidic and more acidic values, and the antral lipid and protein contents with easily accessible, commercially available products, and (4) we identified the most useful composition of FeSSGF-V3 for reproducing the two point estimates. For both model drugs, apparent solubility in FeSSGF-V2 and in FEDGAS pH 3 deviated substantially from the corresponding point estimate.
View Article and Find Full Text PDFNanotechnol Sci Appl
January 2025
Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, 45363, Indonesia.
Purpose: Improving drug solubility is crucial in formulating poorly water-soluble drugs, especially for oral administration. The incorporation of drugs into mesoporous silica nanoparticles (MSN) is widely used in the pharmaceutical industry to improve physical stability and solubility. Therefore, this study aimed to elucidate the mechanism of poorly water-soluble drugs within MSN, as well as evaluate the impact on the dissolution and physical stability.
View Article and Find Full Text PDFHeliyon
January 2025
Department of Microbiology (Biocenter 1, Viikinkaari 9), Faculty of Agriculture and Forestry, University of Helsinki, Finland.
The white rot fungus was investigated for its ability to decolorize the reactive textile dye Reactive Black 5 (RB5) that was co-exposed to CdCl and quantum dots (QDs) consisting of a CdTe core capped with two different hydrophilic organic ligands (NAC and MPA). Without co-exposure, completely decolorizes RB5 within 9 days. The highest inhibitory effect was found for soluble CdCl with an EC of 583 μg l, followed by MPA-QDs (10,628 μg l) and NAC-QDs (17,575 μg l).
View Article and Find Full Text PDFHeliyon
January 2025
Department of Zoological Sciences, Addis Ababa University, 1176, Addis Ababa, Ethiopia.
Nutrients in an aquatic system determine productivity, integrity and ecological status of the aquatic system. However, the excessive enrichment of these nutrients emanating from severe anthropogenic activity has substantially impacted water quality and biodiversity. There is diminutive information available on the water quality and trophic status of the northern Gulf of Lake Tana, Ethiopia due to accessibility difficulties.
View Article and Find Full Text PDFHeliyon
January 2025
Department of Polymer Engineering and Color Technology, Amirkabir University of Technology, P.O. Box 15875-4413, Tehran, Iran.
Development of efficient drug delivery systems remains a critical challenge in pharmaceutical applications, necessitating novel approaches to improve drug loading and release profiles. In this study, a novel method is presented for fabricating crosslinked polydopamine particles (XPDPs) using a water/water Pickering emulsion system. The emulsion is composed of poly(ethylene glycol) and dextran, stabilized by polydopamine (PDA) particles.
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