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The role of KRT18 in lung adenocarcinoma development: integrative bioinformatics and experimental validation.
Discov Oncol
December 2024
School of Pharmacy, Shaoyang University, Shaoyang, 422000, Hunan, China.
Lung adenocarcinoma (LUAD) represents one of the most common subtypes of lung cancer with high rates of incidence and mortality, which contributes to substantial health and economic demand across the globe. Treatment today mainly consists of surgery, radiotherapy, and chemotherapy, but their efficacy in advanced stages is often suboptimal and emphasizes the clear need for new biomarkers and therapeutic targets. Using comprehensive bioinformatics analyses consisting of the Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), Human Protein Atlas (HPA) and Clinical Proteomic Tumor Analysis Consortium (CPTAC), immune infiltration analysis and functional enrichment analysis, and single-cell analysis, we examined the potential of keratin 18 (KRT18) as a candidate biomarker in advanced LUAD.
View Article and Find Full Text PDFNumerical Simulation on Self-Propulsion Characteristics of Bionic Flexible Foil Considering Ground Wall Effect.
Biomimetics (Basel)
December 2024
College of Oceanography, Hohai University, Nanjing 210024, China.
In order to figure out the wall effect on the propulsive property of an auto-propelled foil, the commercial open-source code ANSYS Fluent was employed to numerically evaluate the fluid dynamics of flexible foil under various wall distances. A virtual model of NACA0015 foil undergoing travelling wavy motion was adopted, and the research object included 2D and 3D models. To capture the foil's moving boundary, the dynamic grid technique coupled with the overlapping grid was utilized to realize the foil's positive deformation and passive forward motion.
View Article and Find Full Text PDFKinematic and Aerodynamic Analysis of a Performing Banked Turns in Climbing Flight.
Biomimetics (Basel)
November 2024
Robotics Institute, Beihang University, Beijing 100191, China.
Many flights, with their precise positioning capabilities, have provided rich inspiration for designing insect-styled micro air vehicles. However, researchers have not widely studied their flight ability. In particular, research on the maneuverability of using integrated kinematics and aerodynamics is scarce.
View Article and Find Full Text PDFState Variation in Uptake of Pharmacy-Based CLIA-Waived Testing: Impact of Laws and Regulations.
J Pharm Technol
December 2024
College of Pharmacy, Ferris State University and Collaboration to Advance Pharmacy Enterprises, Grand Rapids, MI, USA.
Community pharmacies have grown to be an increasingly important provider of CLIA-waived tests, just second to physician offices as the venue with the most waivers. Yet, individual variation is still observed across states with respect to the percentage of pharmacies holding a CLIA-waiver, with a reported range of 10.7% in Massachusetts to 87.
View Article and Find Full Text PDFEffects of missing data imputation methods on univariate blood pressure time series data analysis and forecasting with ARIMA and LSTM.
BMC Med Res Methodol
December 2024
School of Mathematical & Statistical Sciences, University of Texas Rio Grande Valley, One West University Boulevard, Brownsville, TX, 78520, USA.
Background: Missing observations within the univariate time series are common in real-life and cause analytical problems in the flow of the analysis. Imputation of missing values is an inevitable step in every incomplete univariate time series. Most of the existing studies focus on comparing the distributions of imputed data.
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