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Taste Preference and Metabolic Rate of Trehalose in Chickens.
J Poult Sci
January 2025
Section of Oral Neuroscience, Graduate School of Dental Science, Kyushu University, Fukuoka 812-8582, Japan.
Trehalose (Tre) is composed of two molecules of D-glucose joined by an α,α-1,1 glucosidic linkage. Because Tre is utilized by the gut microbiome and enhances gut immunity in chickens, it is used as a feed ingredient. However, taste preference and metabolic dynamics of Tre in chickens are not fully understood.
View Article and Find Full Text PDFOpen-label evaluation of oral trehalose in patients with neuronal ceroid lipofuscinoses.
J Neurol
January 2025
IRCCS Stella Maris Foundation, Via Dei Giacinti 2, 56128, Pisa, Italy.
The neuronal ceroid lipofuscinoses (NCLs) are incurable pediatric neurodegenerative diseases characterized by accumulation of lysosomal material and dysregulation of autophagy. Given the promising results of treatment with trehalose, an autophagy inducer, in cell and animal models of NCL, we conducted an open-label, non-placebo-controlled, non-randomized 12-month prospective study in NCL patients receiving oral trehalose (4 g/day). All were treated with a commercially available formulation for 6 months, followed by a 6-month washout.
View Article and Find Full Text PDFIsoniazid and nicotinic hydrazide hybrids mitigate trehalose-6,6'-dimycolate-induced inflammatory responses and pulmonary granulomas via Syk/PI3K pathways: A promising host-directed therapy for tuberculosis.
Biomed Pharmacother
January 2025
Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup 56212, Republic of Korea. Electronic address:
Granulomas, dense clusters of immune cells and bacteria, are critical barriers in tuberculosis (TB) treatment. Recent advancements in TB management have highlighted granuloma control as a potential host-directed therapy (HDT) strategy. Although isoniazid (INH) is the first-line drug for TB therapy, its efficacy is limited to non-replicating Mycobacterium tuberculosis (Mtb) under granulomatous conditions, necessitating the development of more effective derivatives.
View Article and Find Full Text PDFImpact of solid content on the bulk properties of lyophilized powders.
Int J Pharm
December 2024
Evelo Biosciences, Cambridge, MA 02139, USA. Electronic address:
Interest in oral delivery of biological drug products, commonly prepared through lyophilization, is surging. Typically, low solid content solutions are employed for lyophilization to enhance mass transfer and minimize drying time. Yet, this approach often results in lyophilized powders with low bulk density and poor flowability, challenging downstream processing steps that are required for oral product development.
View Article and Find Full Text PDFEffect of oral trehalose supplementation on inflammation and wound healing in patients with peri-trochanteric fractures: study protocol for a randomised clinical trial.
BMJ Open
December 2024
Department of Orthopedics, Taleghani Hospital Research Development Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Article Synopsis
- Peri-trochanteric fractures are common in older adults with osteoporosis and lead to significant health issues, including pain, immobility, and increased mortality, especially in Nordic countries.
- The study is a randomized, double-blind trial involving 64 patients to test the effects of trehalose, a sugar with potential wound healing benefits, against a placebo over 12 weeks, monitoring inflammation and healing.
- Ethical approval has been obtained from Shahid Beheshti University, with the trial registered in the Iranian Clinical Trials database for transparency and accountability.
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