Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme

1715-53204542020AprApplied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolismeAppl Physiol Nutr MetabThe effects of chronic Δ-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) use on cerebral glucose metabolism in multiple sclerosis: a pilot study.450452450-45210.1139/apnm-2019-0634This exploratory pilot study investigated the effects of chronic Δ-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) on cerebral glucose metabolism in people with multiple sclerosis (PwMS). Compared with nonusers, THC users had hypermetabolism of 3 regions (p < 0.039, d >1.17) in left temporal areas, while CBD users had hypometabolism of 5 regions (p < 0.032, d > 1.31) in left temporal areas. This study highlights the need to discriminate between THC and CBD in future cannabis studies. Novelty Chronic THC and CBD use had disparate effects on cerebral glucose metabolism in PwMS.WorkmanCraig DCDDepartment of Health and Human Physiology, University of Iowa, Iowa City, IA 52242, USA.KindredJohn HJHDepartment of Physical Therapy, Medical University of South Carolina, Charleston, SC 29425, USA.Boles PontoLaura LLLDepartment of Radiology, University of Iowa Health Clinics, Iowa City, IA 52242, USA.KamholzJohnJDepartment of Neurology, University of Iowa Health Clinics, Iowa City, IA 52242, USA.RudroffThorstenTDepartment of Health and Human Physiology, University of Iowa, Iowa City, IA 52242, USA.Department of Neurology, University of Iowa Health Clinics, Iowa City, IA 52242, USA.engJournal Article20191216