AI Article Synopsis
- Parvalbumin exists in two main forms, with concentrations of 2.5 and 3.2 g per kg in fresh muscle.
- The two forms are 81% similar in amino acid composition but have distinct immune properties.
- Parvalbumin binds magnesium alongside calcium, and research suggests it may stay in a magnesium-bound state during muscle contraction and relaxation, which is important for understanding its function.
Article Abstract
1. Parvalbumin exists in two major forms, amounting to 2.5 and 3.2 g per kg of fresh muscle. 2. The composition divergence index between both forms, calculated from their amino acid composition, indicates 81% sequence identity; however both isoparvalbumins are immunologically distinct. 3. Beside Ca2+, perch parvalbumin binds 2 g atoms Mg2+ per mol with a dissociation constant of 10(-5) M. 4. Determination of the affinity for magnesium is of particular importance as there are indications that, in vivo, parvalbumin can remain in the Mg2+-state during the contraction-relaxation cycle instead of switching from the Ca2+-to the Mg2+-state and vice versa.
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| http://dx.doi.org/10.1016/0305-0491(79)90037-3 | DOI Listing |
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