AI Article Synopsis
- Arabinomannan (AM) polysaccharides serve as important clinical biomarkers for Mycobacterium tuberculosis (MTB) infections, affecting how host cells respond and how macrophages are activated.
- Understanding these AM oligosaccharides is crucial for creating new diagnostic tools and therapeutic agents for tuberculosis.
- The study utilized automated glycan assembly (AGA) to efficiently synthesize various AM oligosaccharides with specific linkages, improving the synthesis process through a capping step and optimized reaction conditions.
Article Abstract
Arabinomannan (AM) polysaccharides are clinical biomarkers for (MTB) infections due to their roles in the interaction with host cells and interference with macrophage activation. Collections of defined AM oligosaccharides can help to improve the understanding of these polysaccharides and the development of novel therapeutical and diagnostic agents. Automated glycan assembly (AGA) was employed to prepare the core structure of AM from MTB, containing α-(1,6)-Man, α-(1,5)-Ara, and α-(1,2)-Man linkages. The introduction of a capping step after each glycosylation and further optimized reaction conditions allowed for the synthesis of a series of oligosaccharides, ranging from hexa- to branched dodecasaccharides.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902893 | PMC |
| http://dx.doi.org/10.3762/bjoc.15.288 | DOI Listing |
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