AI Article Synopsis
- The study investigates how samsum ant venom (SAV) affects certain immune cell markers (MHC-II, CD80, and CD86) in rats, focusing on two different injection methods: intraperitoneal and subcutaneous.* -
- Results showed that while both methods increased marker expression on immune cells, the subcutaneous method was more effective and led to changes in lipid levels and oxidative stability.* -
- The findings suggest that SAV stimulates immune response by enhancing antigen presentation capabilities, particularly through the subcutaneous route, which might have implications for understanding ant venoms' effects on immunity.*
Article Abstract
Background: Ant venoms express surface molecules that participate in antigen presentation involving pro- and anti-inflammatory cytokines. This work aims to investigate the expression of MHC-II, CD80 and CD86 on the polymorphonuclear cells (PMNs) in rats injected with samsum ant venom (SAV).
Methods: Rats were divided into three groups - control, SAV-treated (intraperitoneal route, 600 μg/kg), and SAV-treated (subcutaneous route, 600 μg/kg). After five doses, animals were euthanized and samples collected for analysis.
Results: The subcutaneous SAV-trated rats presented decreased levels of glutathione with increased cholesterol and triglyceride levels. Intraperitoneal SAV-treated animals displayed significantly reduced concentrations of both IFN-γ and IL-17 in comparison with the control group. However, intraperitoneal and subcutaneous SAV-treated rats were able to upregulate the expressions of MHC-II, CD80 and CD86 on PMNs in comparison with the control respectively. The histological examination showed severe lymphocyte depletion in the splenic white pulp of the intraperitoneal SAV-injected rats.
Conclusion: Stimulation of PMNs by SAV leads to upregulation of MHC-II, CD 80, and CD 86, which plays critical roles in antigen presentation and consequently proliferation of T-cells. Subcutaneous route was more efficient than intraperitoneal by elevating MHC-II, CD80 and CD86 expression, disturbing oxidative stability and increasing lipogram concentration.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6892565 | PMC |
| http://dx.doi.org/10.1590/1678-9199-JVATITD-2019-0020 | DOI Listing |
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