AI Article Synopsis
- Epigenetic abnormalities, particularly in RNA methylation, are significant in the development of hematological malignancies like acute leukemia (AL).
- m6A methylation, a common and well-researched type of RNA methylation, influences various biological functions and disease processes.
- Recent research highlights m6A methylation's role in the emergence, progression, and drug resistance of acute leukemia, which is the main focus of this review.
Article Abstract
Epigenetic abnormalities play an important role in the pathogenesis of hematological malignancies, especially acute leukemia (AL). Similar to DNA methylation and histone modifications, RNA methylation is another important epigenetic modification. m6A methylation is one of the most prevalent and extensively studied RNA methylation. m6A methylation is involved in many biological and pathological process. Recent studies have found that m6A methylation is involved in the occurrence, development and drug-resistance of AL. This review focuses on the research progress of m6A methylation in AL.
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| http://dx.doi.org/10.19746/j.cnki.issn.1009-2137.2019.06.050 | DOI Listing |
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