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Seroprevalence of anti-ToxoplasmaIgG among the human population in Indonesia: a systematic review and meta-analysis.
BMC Public Health
January 2025
Medicine Program, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.
Background: Toxoplasma gondii is a ubiquitous parasite that can cause significant complications when it infects pregnant women and immunocompromised patients. These complications include miscarriage, fetal abnormalities, and fatal cerebral toxoplasmosis. Despite its significance, the true burden of toxoplasmosis in Indonesia remains underexplored.
View Article and Find Full Text PDFInfection with Toxoplasma gondii triggers coagulation at the blood-brain barrier and a reduction in cerebral blood flow.
J Neuroinflammation
January 2025
Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine, 92697, USA.
Background: Immunothrombosis is the process by which the coagulation cascade interacts with the innate immune system to control infection. However, the formation of clots within the brain vasculature can be detrimental to the host. Recent work has demonstrated that Toxoplasma gondii infects and lyses central nervous system (CNS) endothelial cells that form the blood-brain barrier (BBB).
View Article and Find Full Text PDFDeficiencies of Inducible Costimulator (ICOS) During Chronic Infection with Upregulate the CD28-Dependent Cytotoxicity of CD8 T Cells and Their Effector Function Against Tissue Cysts of the Parasite.
Cells
December 2024
Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, KY 40536, USA.
We recently identified that the cerebral mRNA expression of inducible costimulator (ICOS) and its ligand, ICOSL, both significantly increase during the elimination of cysts from the brains of infected mice by the perforin-mediated cytotoxic activity of CD8 T cells. In the present study, we examined the role of ICOS in activating the effector activity of CD8 T cells in response to the presence of cysts in infected mice. Following the adoptive transfer of splenic CD8 T cells from chronically infected ICOS-deficient (ICOS) and wild-type (WT) mice to infected SCID mice, fewer CD8 T cells were detected in the brains of the recipients of ICOS CD8 T cells than the recipients of WT CD8 T cells.
View Article and Find Full Text PDFDisseminated histoplasmosis and presumptive CNS toxoplasmosis-associated immune reconstitution inflammatory syndrome in a patient with HIV/AIDS: a case report.
BMC Infect Dis
December 2024
Division of Infectious Diseases, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, USA.
Article Synopsis
- A 55-year-old woman with HIV/AIDS, adhering to her antiretroviral therapy, was hospitalized due to swallowing difficulties and swollen lymph nodes, revealing a rare case of disseminated histoplasmosis and suspected cerebral toxoplasmosis.
- The diagnosis was confirmed through various tests, including a biopsy, (1-3) -β-glucan assay, and imaging studies.
- This case underscores the challenges of managing opportunistic infections during immune recovery in HIV patients and the importance of vigilant monitoring and comprehensive diagnostics.
Neurosurgical Excision of Isolated Cerebral Toxoplasmosis in an HIV Positive Patient: A Long-Term Successful Outcome.
Neurol India
November 2024
Associate Professor, Department of Neurosurgery, Sri Ramachandra Institute of Higher Education and Research (SRIHER), Chennai, Tamil Nadu, India.
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